血清降钙素原在新生儿脓毒症诊断中的临床价值

Clinical value of serum procalcitonin in diagnosis of neonatal sepsis

目的探讨血清降钙素原（PCT)在新生儿脓毒症发病过程的临床诊断价值。方法采用罗氏电化学发光法对406例非脓毒症（非脓毒症组）和154例脓毒症（脓毒症组）住院新生儿进行PCT水平检测。结果以PCT>0.5ng/mL为阳性标准，PCT诊断新生儿脓毒症的灵敏度、特异度、阳性预测值、阴性预测值、阳性似然比、阴性似然比和粗符合率分别为96.75%、91.38%、80.98%、98.67%、11.220、0.036和92.86%。脓毒症组PCT阳性率明显高于非脓毒症组，差异有统计学意义（P<0.05)。结论以PCT>0.5ng/mL为阳性标准对新生儿脓毒症的诊断有很高的特异度和灵敏度，在诊断和治疗中有非常高的临床价值。

Objective To investigate the clinical value of serum procalcitonin(PCT)in the pathogenesis of neonatal sepsis.Methods The levels of PCT of406hospitalized neonates with non sepsis(the non sepsis group)and154hospitalized neonates with sepsis(the sepsis group)were detected by Roche Electrochemiluminescence.Results With PCT^0.5ng/mL as positive stand-ard,the sensitivity,specificity,positive predictive value,negative predictive value,positive and negative likelihood ratios and crude coincidence rate of PCT diagnosis of neonatal sepsis were96.75%,91.38%,80.98%,98.67%,11.220,0.036and92.86%respec-tively.The positive rate of PCT in the sepsis group was higher than that in the non sepsis group,the difference was statistically sig-nificant(P<Co.05).Conclusion With PCT^0.5ng/mL as positive standard,it has very high sensitivity and specificity in diagno-sis of neonatal sepsis,which is very high clinical value in the diagnosis and treatment.