骨碱性磷酸酶检测在儿童佝偻病早期诊断中的价值

Value of bone alkaline phosphatase detection in early diagnosis of rickets of children

目的探讨骨碱性磷酸酶（BALP)对儿童佝偻病早期诊断的临床意义，了解该地区儿童佝偻病的发病率。方法收集门诊患儿2334例，按年龄界限分为婴儿组、幼儿组、学龄前组和学龄期组，采用全血干化学和免疫浓缩技术测定小儿血中BALP活性。结果婴儿组中BALP>250U/L的检出率为34.32%，且患儿年龄越小检出率越高，BALP检出率无性别差异。结论儿童BALP活性检测对维生素D缺乏引起的佝偻病的早期诊断有重要临床价值，儿童佝偻病预防应从围生期开始，及时检测BALP水平，以便早发现早治疗。

To investigate the clinical significance of bone alkaline phosphatase(BALP)in the early diagnosis of rick-ets of childrenand understand the incidence of rickets of children in the area.Methods2334children in outpatient department were collected and divided into thebaby group,theinfant group,the preschool group and the school-age group according to age limit.BALP activity in blood of children was measured by the whole blood dry chemistry and immune concentration technique.Results The detection rate of BALP>250U/L in the baby group was34.32%.The younger the patient,the higher the detection rate.There was no sex difference in the detection rate of BALP.Conclusion The detection of BALP activity in children has important clinical value in the early diagnosis of ricketscaused by vitamin D deficiency.Prevention of rickets in children shall begin from peri-natal period and detect the level of BALP in time so that early detection and early treatment can be achieved.