布地奈德联合沙丁胺醇雾化吸入改善毛细支气管炎患儿免疫功能的探讨

Discussion on aerosol inhalation of budesonide and salbutamol for improving the immune function of children with bronchiolitis

目的:探讨布地奈德联合沙丁胺醇雾化吸入对毛细支气管炎患儿免疫功能的改善作用。方法:收治毛细支气管炎患儿80例,随机平分两组。单一用药组使用布地奈德混悬液进行治疗,联合用药组在此基础上联合使用沙丁胺醇雾化吸入治疗,比较两组患儿治疗前后的免疫功能变化情况。结果:经治疗,两组患儿的血清IgE水平、CD8^+水平均较治疗前显著降低,CD4^+水平、CD4^+/CD8^+水平较治疗前均显著升高,治疗前后对比,差异具有统计学意义(P<0.05),而联合用药组的变化更为明显;两组治疗后相比,差异具有统计学意义(P<0.05)。结论:联合使用布地奈德与沙丁胺醇雾化吸入治疗小儿毛细支气管炎,能够更好地改善患儿的免疫功能。

Objective:To investigate aerosol inhalation of budesonide and salbutamol for improving the immune function of children with bronchiolitis.Methods:80children with bronchiolitis were selected.They were randomly divided into the two groups on average.The monotherapy group was treated with budesonide suspension.On this basis,the combined treatment group was treated with salbutamol inhalation.The changes of immune function before and after treatment were compared between the two groups.Results:After treatment,the serum IgE levels and CD8+levels of the two groups were significantly lower than those before treatment.The levels of CD4+and CD4+/CD8+were significantly higher than those before treatment.Before and after treatment,the difference was statistically significant(P<0.05).The changes of the combined medication group were more obvious,and the difference between groups after treatment was statistically significant(P<0.05).Conclusion:Aerosol inhalation of budesonide and salbutamol in the treatment of children with bronchiolitis can better improve the immune function of children.