肝脏疾病应用D-二聚体、抗凝血酶Ⅲ、凝血因子Ⅷ、凝血因子Ⅸ检测对诊断患者病情的意义

Significance of D-two dimers,antithrombin Ⅲ,coagulation factor Ⅷ, coagulation factor Ⅸ detection in diagnosis of liver diseases

目的:探讨肝脏疾病应用D-二聚体、抗凝血酶Ⅲ、凝血因子Ⅷ、凝血因子Ⅸ检测对患者病情诊断的意义。方法:收治肝脏疾病患者60例,选择健康体检者20例,分为肝硬化组、肝炎组、肝癌组、健康人群组,分别检测血浆D-二聚体、抗凝血酶Ⅲ、凝血因子Ⅷ、凝血因子Ⅸ。结果:与健康人群组相比,肝癌与肝硬化组的D-二聚体含量上升明显,3组肝脏疾病患者的凝血因子Ⅷ显著升高;肝癌组的凝血因子Ⅸ较健康人群组显著升高;肝炎组和肝硬化组的抗凝血酶Ⅲ较健康人群组活性显著降低。结论:对肝脏疾病行病情诊断时,应加强检测血浆中D-二聚体、抗凝血酶Ⅲ、凝血因子Ⅷ、凝血因子Ⅸ,以提高病情诊断准确性。

Objective:To investigate the significance of D-two dimers,antithrombinⅢ,coagulation factorⅧ,coagulation factorⅨdetection in the diagnosis of liver diseases.Methods:60patients with liver disease were selected,20healthy subjects were selected.They were divided into the cirrhosis group,the hepatitis group,the liver cancer group and the healthy population group.They were given D-two dimers,antithrombinⅢ,coagulation factorⅧ,coagulation factorⅨdetection.Results:Compared with healthy population,the contents of D-two dimers in the liver cancer group and the cirrhosis group were obviously increased,coagulation factorⅧof three liver disease groups was significantly increased.Compared with healthy population group,the coagulation factorⅨof the liver cancer group was significantly increased.Compared with healthy population group,the activity of antithrombinⅢof the cirrhosis group and the hepatitis group was markedly decreased.Conclusion:For diagnosis of liver disease,we should strengthen the plasma D-two dimers,antithrombinⅢ,coagulation factorⅧ,coagulation factorⅨdetection,in order to improve the diagnostic accuracy of the disease.