成都社区女性骨质疏松及骨质疏松骨折患者维生素D水平研究

The study of 25-hydroxyvitamin D status of patients with osteoporosis and osteoporotic fracture of women in Chengdu community

目的:调查成都社区老年女性骨质疏松和骨质疏松骨折患者维生素D水平,探讨其对骨质疏松和骨折的影响。方法:选取>50岁女性200例,有近1年内的骨密度和椎体DR片检查结果,其中正常人80例,骨质疏松74例,骨质疏松骨折46例。均测量血清25-OH维生素D水平,并比较骨质疏松组和骨折组维生素D、骨密度差异,分析维生素D和骨密度相关性。结果:200例女性中,维生素D缺乏68例(34%),不足76例(38%),充足56例(28%)。骨质疏松组和骨质疏松骨折组25-OH维生素D水平、骨密度均有显著性差异,25-OH维生素D和骨密度有一定相关性。结论:成都社区老年女性骨质疏松患者25-OH维生素D水平明显低下,因此治疗上补充维生素D是非常必要的。

Objective:To investigate25-hydroxyvitamin D of patients with osteoporosis and osteoporotic fracture of women in Chengdu community.To explore the effect of25-hydroxyvitamin D on osteoporosis and osteoporotic fracture.Methods:200elderly women over50years old were selected,all patients had bone mineral density and vertebral DR findings for nearly1year.There were80normal subjects,74osteoporotic patients and46osteoporotic fractures.The serum25(OH)VD levels were measured for all patients.The difference of vitamin D and bone mineral density between the osteoporosis group and the fracture group was analyzed,and the correlation between vitamin D and bone mineral density was analyzed.Results:Among the200women,vitamin D deficiency was found in68cases(34%),vitamin D was not enough in76cases(38%),and vitamin D was adequate in56cases(28%).The25(OH)VD level and bone mineral density were significantly different in the osteoporosis group and the osteoporotic fracture group,25(OH)VD has some correlation with bone mineral density.Conclusion:Vitamin D inadequacy existed generally in senile women with osteoporosis in Chengdu.It is necessary to supplement vitamin D for osteoporosis therapy.