FcRL3(-169T/C)和FOXP3(-2383T/C)基因多态性与子宫内膜异位症的发病风险

Genetic Polymorphisms of FcR L3(-169T/C) and FOXP3(-2398T/C)with the Risk of Endometriosis

目的:探讨Fc受体样3(Fc RL3)(-169T/C)和叉头样转录因子3(FOXP3)(-2383T/C)基因多态性与子宫内膜异位症(EMs)易感性的关系。方法:检索中国知网、万方、中国生物医学文献数据库(CBM)、Pubmed、Embase等中、英文数据库中发表的关于Fc RL3(-169T/C)和FOXP3(-2383T/C)基因多态性与EMs易感性的文献。对文献进行质量评价、筛选和提取相关病例对照研究资料,使用R软件进行Meta分析,计算合并的比数比(OR)及其95%可信区间(CI)。结果:共纳入文献7篇(其中Fc RL3相关文献5篇,累计病例组883例,对照组1 241例;FOXP3相关文献3篇,累计病例组679例,对照组690例)。Fc RL3与FOXP3在等位基因对比模型(T vs.C)中,Fc RL3:OR=2.40,95%CI:1.77~3.27,Z=5.57,P<0.000 1;FOXP3:OR=5.95,95%CI:5.05~7.01,Z=21.40,P<0.000 1。而在其余分析模型中:杂合子模型(TC vs.CC)(Fc RL3:OR=1.23,95%CI:0.80~1.88,Z=0.93,P=0.352;FOXP3:OR=1.75,95%CI:0.80~3.83,Z=1.39,P=0.165);纯合子模型(TT vs.CC)(Fc RL3:OR=1.27,95%CI:0.54~2.97,Z=0.99,P=0.323;FOXP3:OR=0.69,95%CI:0.11~4.33,Z=-0.40,P=0.69);隐性基因对比模型(TT vs.TC+CC)(Fc RL3:OR=1.25,95%CI:0.72~2.14,Z=0.79,P=0.427;FOXP3:OR=1.40,95%CI:0.66~2.95,Z=0.88,P=0.380)以及显性基因对比模型(TT+TC vs.CC)(Fc RL3:OR=0.90,95%CI:0.50~1.64,Z=-0.34,P=0.737;FOXP3:OR=1.65,95%CI:0.99~2.73,Z=1.94,P=0.053)。结论:Fc RL3(-169T/C)和FOXP3(-2383T/C)基因多态性可增加EMs的发病风险。

Objective:In this study,a meta-analysis was performed to clarify the relationship between the genetic polymorphisms of Fc Receptor Like-3(FcRL3)(-169T/C)and Forkhead box P3(FOXP3)(-2383T/C)and the risk of endometriosis(EMs).Methods:Published literatures from PubMed,Embase,CNKI,WanFang,CBM databases were retrieved.Pooled odds ratio(OR)with95%confidence interval(CI)was calculated using fixed-or random-effects model according to the heterogeneity.Results:Five studies with883cases and1241controls for FcRL3gene polymorphism and three studies with679cases and690controls for FOXP3gene polymorphism were included in the final meta-analysis.The polymorphisms of FcRL3and FOXP3was associated with EMs risk in allele model(FcRL3:OR=2.40,95%CI:1.77-3.27,Z=5.57,P<0.0001;FOXP3:OR=5.95,95%CI:5.05-7.01,Z=21.40,P<0.0001).And in other models:heterozygote model(TC vs.CC)(FcRL3:OR=1.23,95%CI:0.80-1.88,Z=0.93,P=0.352;FOXP3:OR=1.75,95%CI:0.80-3.83,Z=1.39,P=0.165);homozygote model(TT vs.CC)(FcRL3:OR=1.27,95%CI:0.54-2.97,Z=0.99,P=0.323;FOXP3:OR=0.69,95%CI:0.11-4.33,Z=-0.40,P=0.69);Recessive model(TT vs.TC+CC)(FcRL3:OR=1.25,95%CI:0.72-2.14,Z=0.79,P=0.427;FOXP3:OR=1.40,95%CI:0.66-2.95,Z=0.88,P=0.380);Dominant model(TT+TC vs.CC)(FcRL3:OR=0.90,95%CI:0.50-1.64,Z=-0.34,P=0.737;FOXP3:OR=1.65,95%CI:0.99-2.73,Z=1.94,P=0.053).Conclusions:Our analysis showed that the polymorphisms of FcRL3(-169T/C)and FOXP3(-2383T/C)were risk factors for EMs.