儿童尿液中PAEs代谢物浓度与居室装饰材料的关联

Associations between urinary concentrations of PAEs metabolites and residential decoration materials

基于2013~2014年在上海地区开展的中国室内环境与儿童健康研究,分析了434位学龄儿童的晨尿PAEs代谢物浓度总体分布情况;并根据随访问卷获取的居室建筑特性信息,分析了PAEs代谢物与居室地板和墙面装饰材料的关系.我们利用HPLC-MS/MS法对儿童晨尿中10种PAEs代谢物进行定量检测,并采用非参数检验法比较了居室使用不同类型的地板和墙面装饰材料的儿童晨尿中PAEs代谢物的浓度差异.除MBz P(检出率:51.2%)和MCHP(9.9%)外,其他8种PAEs代谢物检出率均在90%以上.代谢物浓度[中位数(标准差)]从高到低依次为:Mn BP,58.1(205.9)μg/L;Mi BP,46.2(119.2)μg/L;MECPP,39.0(111.1)μg/L;MEHHP,24.7(92.6)μg/L;MEOHP,14.5(45.1)μg/L;MMP,11.4(21.4)μg/L;MEP,10.1(51.5)μg/L;MEHP,4.5(19.0)μg/L;MBz P,0.2(4.3)μg/L;MCHP,<LOD(0.2)μg/L.结果表明,男孩的代谢物浓度普遍高于女孩;10岁儿童的代谢物浓度普遍低于<10岁的儿童;夏季代谢物浓度普遍高于其他季节.中国儿童的DMP和DEHP代谢物浓度明显高于其他国家或地区.相对于水泥地板,客厅使用实木地板和复合木地板的儿童Mi BP浓度明显更高;相对于实木地板,卧室使用复合木地板的儿童MEP和Mn BP浓度明显更高;相对于石灰墙面,使用乳胶漆墙面和油漆墙面的儿童Mi BP浓度明显更高.结果显示上海地区学龄儿童尿液中PAEs代谢物个体水平存在较大差异;总体水平上存在性别、年龄和检测季节的差异.居室使用复合木地板,乳胶漆和油漆等新型建材可能会明显增加儿童的PAEs暴露量.

434morning urinary samples of school-age children accompanied by the characteristics information of their residences were obtained from rom the CCHH(China,Children,Homes,Health)study in Shanghai during2013~2014.The overall distributions for urinary concentrations of PAEs metabolites and their associations with household decoration materials(floor and wall coverings)were investigated.Ten PAEs metabolites were analyzed by HPLC-MS/MS(high-performance liquid chromatography with tandem mass spectrometric detection).Non-parametric test was preformed to compare the concentration differences of PAEs metabolites among children living in the environment with different floor and wall coverings materials.The detection rates of these PAEs metabolites were above90%,except for MBzP(51.2%)and MCHP(9.9%).The median concentrations(standard deviation)of these metabolites from high to low were as follows:MnBP,58.1(205.9)μg/L;MiBP,46.2(119.2)μg/L;MECPP,39.0(111.1)μg/L;MEHHP,24.7(92.6)μg/L;MEOHP,14.5(45.1)μg/L;MMP,11.4(21.4)μg/L;MEP,10.1(51.5)μg/L;MEHP,4.5(19.0)μg/L;MBzP,0.2(4.3)μg/L;MCHP,<LOD(0.2)μg/L.Generally,the median concentrations among boys were notably higher than those among girls.The median concentrations among10year-old children were notably lower than those among less than10year-old children.The median concentration among children who were inspected in summer were notably higher than those in other seasons.Moreover,DMP and DEHP metabolites among children in China are notably higher than those of children in other countries and regions.Compared with cement,median concentrations of MiBP were notably higher among children who lived in the residence with solid wood and laminated wood as floor covering in the living room.Compared with solid wood,median concentrations of MEP and MnBP were notably higher among children who lived in the residence with laminated wood as floor covering in children's bedroom.Compared with lime,median concentrations of MiBP were notably higher among children who lived in the residence with emulsion paint and oil paint as floor covering.These results indicated that there were large differences on urinary concentrations of PAEs metabolites had in individually among Shanghai children.In general,urinary concentrations of PAEs metabolites had differences with respect to the child's gender,age and inspection season.Furthermore using laminated wood,emulsion paint and oil paint in the residences may increase the level of PAEs exposures among children.