地特胰岛素联合瑞格列奈治疗2型糖尿病的临床疗效观察

Observation on clinical efficacy of insulin detemir combined with repaglinide in the treatment of type 2 diabetes

目的探讨地特胰岛素联合瑞格列奈治疗2型糖尿病的临床疗效。方法 120例2型糖尿病患者,采用动态化随机单双号的方式分为对照组和观察组,各60例。对照组采用瑞格列奈进行治疗,观察组患者在对照组基础上加用地特胰岛素进行治疗,对比两组患者治疗效果。结果观察组患者显效48例,有效10例,无效2例,总有效率为96.67%;对照组患者显效28例,有效20例,无效12例,总有效率为80.00%,观察组总有效率明显高于对照组,差异有统计学意义(P<0.05)。治疗前两组患者空腹血糖(FPG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1c)、空腹C肽以及餐后2 h C肽水平比较差异无统计学意义(P>0.05);治疗后观察组FPG、2 h PG、HbA1c、空腹C肽以及餐后2 h C肽明显优于对照组,差异有统计学意义(P<0.05)。观察组不良反应发生率明显低于对照组,差异有统计学意义(P<0.05)。结论地特胰岛素联合瑞格列奈可以有效治疗2型糖尿病,降低低血糖发生率,值得推广。

Objective To investigate and discuss the clinical efficacy of insulin detemir combined with repaglinide in the treatment of type2diabetes.Methods A total of120type2diabetes patients were divided by dynamic random and odd and even numbers into control group and observation group,with60cases in each group.The control group was treated with repaglinide,and the observation group was treated with insulin detemir on the basis of the control group.Treatment effect in two groups was compared.Results The observation group had48excellent cases,10effective cases and2ineffective cases,with total effective rate as96.67%,while the control group had28excellent cases,20effective cases and12ineffective cases,with total effective rate as80.00%.The observation group had obviously higher total effective rate than the control group,and the difference had statistical significance(P<0.05).Before treatment,there were no statistically significant difference in fasting blood glucose(FPG),2h postprandial glucose(2h PG),glycosylated hemoglobin(HbA1c),fasting C peptide,and2h postprandial C peptide levels(P>0.05).After treatment,the observation group had obviously better FPG,2h PG,HbA1c,fasting C peptide and2h postprandial C peptide than the control group,and their difference had statistical significance(P<0.05).The observation group had obviously lower incidence of adverse reactions than the control group,and the difference had statistical significance(P<0.05).Conclusion Combination of insulin detemir and repaglinide is effective in treating type2diabetes,and it can reduce the incidence of hypoglycemia.So it is worthy of promotion.