沙格列汀联合二甲双胍对2型糖尿病的疗效研究

Study on efficacy of saxagliptin combined with metformin for type 2 diabetes mellitus

目的探讨沙格列汀联合二甲双胍对2型糖尿病的疗效。方法 80例2型糖尿病患者,随机分为对照组及试验组,各40例。对照组采取阿卡波糖联合二甲双胍治疗,试验组采取沙格列汀联合二甲双胍治疗。比较两组患者治疗后的空腹血糖(FBG)、餐后2 h血糖(2 h PBG)、糖化血红蛋白(Hb A1c)水平、体质量指数(BMI)。结果治疗后,试验组Hb A1c(6.36±1.11)%、BMI(20.53±3.55)kg/m2、FBG(6.32±1.20)mmol/L、2 h PBG(9.77±1.88)mmol/L均优于对照组(8.26±1.13)%、(23.06±3.78)kg/m2、(7.74±1.56)mmol/L、(11.50±2.43)mmol/L,差异均有统计学意义(P<0.05)。结论采取沙格列汀联合二甲双胍治疗2型糖尿病,可以明显降低患者餐前、餐后血糖和Hb A1c值,值得在临床推广。

Objective To investigate the efficacy of saxagliptin combined with metformin for type2diabetes mellitus.Methods A total of80type2diabetes mellitus patients were randomly divided into control group and experimental group,with40cases in each group.The control group was treated with acarbose and metformin,and the experimental group was treated with saxagliptin and metformin.Comparison were made on fasting blood glucose(FBG),2h postprandial blood glucose(2h PBG),glycosylated hemoglobin(HbA1c)level and body mass index(BMI)between the two groups after treatment.Results After treatment,the experimental group had better HbA1c as(6.36±1.11)%,BMI as(20.53±3.55)kg/m2,FBG as(6.32±1.20)mmol/L and2h PBG as(9.77±1.88)mmol/L than(8.26±1.13)%,(23.06±3.78)kg/m2,(7.74±1.56)mmol/L and(11.50±2.43)mmol/L in the control group,and their difference had statistical significance(P<0.05).Conclusion Combination of saxagliptin and metformin can obviously reduce the blood glucose and HbA1c value of patients before and after meal,and it is worthy of clinical popularization.