喜炎平注射液的循证安全性评估

Evidence-based Safety Assessment of Xiyanping Injection

目的:对喜炎平注射液的非临床和临床安全性进行评估,为临床用药决策提供有益参考。方法:系统检索喜炎平注射液的非临床和临床安全性评价文献并进行质量评价,对检索到的文献进行定性和定量综述。结果:喜炎平注射液在一般药理学、急性毒性、长期毒性、致敏性、体外溶血、遗传毒性等方面都有较高的安全性。喜炎平注射液与常规抗感染治疗具有相似的不良反应发生率,在未成年人群中的安全性高。结论:喜炎平注射液的非临床和临床安全性较高。

Objective:To assess non-clinical and clinical security of xiyanping injection and provide a reference for clinical decision.Methods:We searchedliteratures systematically and made qualitative and quantitative reviews.Results:Xiyanping injection showed high security in general pharmacologicalstudies,acute toxicity,long-term toxicity,sensitization,hemolysis and genotoxicity.Xiyanping injection had similar adverse effects rate with conventionalanti-infective therapy and had high security in children.Conclusion:Xiyanping injection had high non-clinical and clinical security.