胺碘酮联合美托洛尔对急性心肌梗死并发快速心律失常患者心功能恢复的影响

Effects of Amiodarone Combined with Metoprolol on Cardiac Function Recovery in Patients with Acute Myocardial Infarction Complicated with Rapid Arrhythmia

目的:探讨胺碘酮联合美托洛尔对急性心肌梗死并发快速心律失常患者心功能恢复的影响。方法:选取临颍县人民医院2014年6月至2016年7月71例急性心肌梗死并发快速心律失常患者,按照随机数字表法分组,对照组35例口服0.2g胺碘酮治疗,观察组36例于对照组基础上加服25mg美托洛尔治疗,均治疗2个月,观察比较两组临床治疗效果及心功能各指标[心输出量(CO)、左室射血分数(LVEF)、左室舒张末期内径(LVEDD)]变化情况,并统计两组不良反应发生情况及生活质量评分(QOL)。结果:观察组治疗总有效率为91.67%(33/36),高于对照组71.43%(25/35),差异具有统计学意义(P<0.05);治疗2个月后观察组CO及LVEF均高于对照组,LVEDD小于对照组,差异具有统计学意义(P<0.05);观察组不良反应发生率为11.11%(4/36),对照组为8.57%(3/35),组间比较差异无统计学意义(P>0.05);观察组治疗2个月后QOL评分高于对照组,差异具有统计学意义(P<0.05)。结论:胺碘酮联合美托洛尔可改善急性心肌梗死并发快速心律失常患者心功能,提高疗效及生活质量,且安全性高。

Objective:To explore the effects of amiodarone combined with metoprolol on cardiac function recovery in patients with acute myocardialinfarction complicated with rapid arrhythmia.Methods:From June2014to July2016,71patients with acute myocardial infarction complicated withrapid arrhythmia in the hospital were randomly divided into control group(n=35)and observation group(n=36).The control group was treated with0.2g amiodarone,the observation group was treated with25mg metoprolol on the basis of the control group,and both groups were treated for2months.Clinical treatment and indicators of cardiac function(Cardiac output(CO),left ventricular ejection fraction(LVEF),left ventricular end diastolicdiameter(LVEDD)]of the two groups were analyzed,besides,adverse events and quality of life score(QOL)of the two groups were statisticallyanalyzed as well.Results:The total effective rate was91.67%(33/36)in the observation group and71.43%(25/35)in the control group,the differencewas statistically significant(P<0.05);After treatment for2months,the levels of CO and LVEF in the observation group were higher than those in thecontrol group,LVEDD was lower than that in the control group,the difference was statistically significant(P<0.05);The adverse reactions incidencein the observation group was11.11%(4/36)and8.57%(3/35)in the control group,there was no significant difference between the two groups(P>0.05);The QOL score of the observation group was higher than that of the control group after2months of treatment(P<0.05).Conclusion:Amiodaronecombined with metoprolol can improve cardiac function,treatment efficacy and quality of life in patients with acute myocardial infarction complicatedwith rapid arrhythmia,and high safety.