摘要
胰高血糖素样肽-1(glucagon-like peptide-1,GLP-1)是小肠L细胞分泌的肠促胰素,通过刺激胰岛素分泌和抑制胰高血糖素释放等机制降低血糖。近年来越来越多的研究显示GLP-1具有独立于降糖之外的肾脏保护作用。GLP-1的肾脏保护作用可能是多重机制共同作用的结果,包括GLI-1受体(glucagon-like peptide-1 receptor,GLP-1R)依赖性和非依赖性途径,其中受体依赖性途径更重要。
Glucagon-like peptide-1(GLP-1)is an incretin hormone secreted from enteroendocrine L cells,which control glycemia by stimulatinginsulin synthesis and inhibiting glucagon secretion.Several studies have shown that GLP-1has renal protective effects independent of glycemiccontrol.The renal protective effects were mediated via several pathways,including GLP-1/GLP-1R dependent and independent mechanisms.
作者
庞萍
臧丽
吕朝晖
PANG Ping;ZANG Li;LYU Zhao-hui(Department of Endocrinology, Hainan branch of Chinese PLA General Hospital, Sanya Hainan 572013, China;Department of Endocrinology,Chinese PLA General Hospital, Beijing 100853)
出处
《药品评价》
CAS
2017年第13期13-17,24,共6页
Drug Evaluation
基金
北京市自然科学基金(项目编号:7172196)
解放军总医院科技创新苗圃基金(项目编号:14KMM05)
