慢性支气管炎治疗中舒利迭的临床应用

Clinical Application of Seretide in the Treatment of Chronic Bronchitis

目的:探讨观察在慢性支气管炎患者临床治疗中使用舒利迭的效果及价值。方法:选取120例慢性支气管炎患者开展对照研究,首先采用随机综合平衡法将其分为常规组与观察组,各60例。常规组与观察组患者分别给予慢性支气管炎常规治疗、常规疗法联合舒利迭治疗。对比临床疗效、治疗前后血气指标、不良反应发生情况。结果:观察组治疗后显效、有效与无效分布情况差异有显著性(P<0.05),且观察组总有效率高达98.33%,常规组仅为86.67%,组间差异有显著性(P<0.05);治疗前两组间动脉血氧分压(Pa O2)和二氧化碳分压(Pa CO2)无显著性差异(P>0.05),治疗后两组Pa O2均较治疗前显著升高(P<0.05),而Pa CO2均较治疗前显著降低(P<0.05),且治疗后观察组与常规组血气指标比较差异也均有显著性(P<0.05);观察组不良反应发生率稍高于常规组(P>0.05)。结论:在慢性支气管炎患者常规疗法的基础上采用舒利迭能够显著改善疗效和动脉血气指标,且并不会显著增加不良反应。

Objective:To discuss and observe the clinical effect and value of seretide in the treatment of chronic bronchitis.Methods:120cases ofpatients with chronic bronchitis were enrolled to carry out a comparative study.Firstly,the patients were randomly divided into routine group andobservation group,with60cases in each group.The routine group and observation group of patients with chronic bronchitis were given routinetreatment and routine therapy combined with seretide treatment,respectively.The clinical efficacy,blood gas indexes before and after treatment andadverse reactions were compared between the two groups.Results:The significant,effective and ineffective distribution in the observation group aftertreatment had a significant difference from that in the routine group,and the total effective rate in the observation group was up to98.33%,which wasonly86.67%in the routine group,and the difference between the groups was significant(P<0.05).The arterial oxygen partial pressure(PaO2)andcarbon dioxide partial pressure(PaCO2)between the two groups before treatment had no significant difference(P>0.05),and the PaO2levels in thetwo groups after treatment were significantly higher than those before treatment(P<0.05),while the PaCO2levels were significantly lower than thosebefore treatment(P<0.05),and the levels of blood gas indexes in the observation group after treatment were significantly different from those in theroutine group(P<0.05).The incidence rate of adverse reactions in the observation group was slightly higher than that in the control group(P<0.05).Conclusion:The application of seretide in chronic bronchitis patients based on the conventional therapy can significantly improve the curative effectand the arterial blood gas indexes,which does not significantly increase the adverse reactions.