尼可地尔治疗慢性缺血性心肌病患者心力衰竭的临床观察

Clinical Observation of Nicorandil in the Treatment of Chronic Ischemic Cardiomyopathy with Heart Failure

目的:探讨尼可地尔治疗慢性缺血性心肌病患者心力衰竭的临床效果。方法:从濮阳市红十字医院2014年2月~2016年7月期间收治的慢性缺血性心肌病患者中选择80例作为此次研究分析的对象,其中40例采用尼可地尔治疗,其余40例采用常规抗心衰药物治疗,比较两组患者治疗前后左室舒张末内径、左心室收缩末内径、左心室射血分数等相关指标改善情况及临床效果。结果:观察组与对照组患者在治疗前的左心室射血分数、左心室收缩末内径以及左心室舒张末内径数值比较接近,P>0.05表示组间差距无统计学意义。经过6个月的治疗,观察组患者的左心室射血分数上升明显,而左心室收缩末内径与左心室舒张末内径则下降明显,表明治疗效果比对照组患者更显著,且P<0.05,有统计学差异存在。对照组于治疗后的总有效率显著低于观察组,且P<0.05,有统计学差异存在。结论:采用尼可地尔治疗慢性缺血性心肌病心力衰竭患者,临床效果显著,能够显著地改善患者的心功能情况,帮助患者尽快恢复健康,具有很高的临床应用价值。

Objective:To investigate the clinical effect of nicorandil in the treatment of heart failure in patients with chronic ischemic cardiomyopathy.Methods:Eighty patients with chronic ischemic cardiomyopathy were enrolled in our hospital from February2014to July2016.40patients weretreated with nicorandil and the remaining40patients were treated with conventional anti-heart failure drugs.The changes of left ventricular diastolicdiameter,left ventricular systolic diameter and left ventricular ejection fraction were compared between the two groups before and after treatment.Results:The value of left ventricular ejection fraction,left ventricular end systolic diameter and left ventricular end diastolic diameter in theobservation group and the control group were close to that before treatment(P>0.05).After6months of treatment,the observation group of patientswith left ventricular ejection fraction increased significantly in Puyang Cheng Shumin,Huimin hospital,and left ventricular end systolic diameter andleft ventricular end diastolic diameter decreased significantly,showed that the treatment effect in patients than the control group significantly(P<0.05).The total effective rate of the control group after treatment was significantly lower than that of the observation group,and there was a statisticallysignificant difference between the two groups(P<0.05).Conclusion:The use of nicorandil in patients with chronic ischemic cardiomyopathy has asignificant clinical effect,can significantly improve the patient's cardiac function,help patients to return to health as soon as possible,thus it has ahigh clinical value.