TN化疗方案联合胸腔镜食管癌根治术对局部晚期食管癌术后RO切除率及生存周期的影响

Effect of TN Chemotherapy Combined with Thoracoscopic Esophageal Carcinoma on RO Resection and Survival Cycle in Patients with Local Advanced Esophageal Carcinoma

目的:探究TN化疗方案联合胸腔镜食管癌根治术对局部晚期食管癌术后RO切除率及生存周期的影响。方法:回顾性分析2013年3月~2014年3月期间在南阳胸科医院接受治疗的晚期食管癌患者共58例。其中29例患者行胸腔镜食管癌根治术,并在术后实施常规化疗方案,该组为对照组;而采用TN化疗方案联合胸腔镜食管癌根治术的患者则为观察组。比较两组患者的手术效果、化疗效果、并发症发生情况以及生存周期。结果:观察组患者的RO切除率为82.76%高于对照组(58.62%),总切除率为100%,高于对照组的82.76%,差异明显(P<0.05)。观察组并发症发生率低于对照组,比较差异具有统计学意义(P<0.05)。观察组术后1年生存率为82.76%(24/29),3年生存率为68.97%(20/29);均高于对照组(58.62%,48.28%),比较差异具有统计学意义(P<0.05)。结论:TN化疗方案联合胸腔镜食管癌根治术对晚期食管癌患者可提高RO切除率,延长生存周期,值得推广。

Objective:To investigate the effect of TN chemotherapy combined with thoracoscopic esophagectomy on RO resection rate and survivalcycle of patients with locally advanced esophageal cancer.Methods:A total of58patients with advanced esophageal cancer who underwent treatmentin our hospital from March2013to March2014were retrospectively analyzed.Twenty-nine patients underwent thoracoscopic esophagectomy,andthe patients were treated with routine chemotherapy.The patients were treated with TN chemotherapy and thoracoscopic esophagectomy.Surgicalresults,chemotherapy,complications and survival cycle were compared between the two groups of patients.Results:The RO resection rate was82.76%in the observation group and58.62%in the control group.The total resection rate was100%,which was higher than that of the control group(82.76%)(P<0.05).The incidence of complications in the observation group was lower than that in the control group,the difference was statisticallysignificant(P<0.05).The1-year survival rate was82.76%(24/29)and the3-year survival rate was68.97%(20/29).The difference was statisticallysignificant(58.62%,48.28%)(P<0.05).Conclusion:TN chemotherapy combined with thoracoscopic esophageal cancer radical surgery can improveRO resection rate and prolong survival cycle in patients with advanced esophageal cancer.