丙泊酚麻醉对幼儿认知功能的影响

Effects of propofol on cognitive function in children undergoing anesthesia

目的:探讨丙泊酚麻醉对幼儿认知功能的影响。方法:收治1~3岁行腹腔镜下疝气修补术患者140例,随机平分两组。观察组采用丙泊酚麻醉,对照A组采用依托咪酯麻醉;两组患儿均给予芬太尼、罗库溴铵;所有患儿均手术前给予芬太尼维持麻醉;另选取健康幼儿70例作为对照B组。分别于手术前1 d、手术后3 d及手术后3个月评价3组认知功能。结果:观察组、对照A组手术后3 d认知功能评分均较手术前1 d下降(P<0.05);观察组及对照A组患儿术后3个月认知功能评分及认知功能障碍发生率与术前比较,差异无统计学意义(P>0.05)。结论:应用丙泊酚或依托咪酯麻醉可致患儿出现不同程度认知功能障碍,但可于术后3个月内自行恢复。

Objective:To investigate the effect of propofol on cognitive function in children undergoing anesthesia.Methods:140patents aged1～3years old underwent laparoscopic hernia repair were selected.They were randomly divided into the two groupson average.The observation group received propofol anesthesia,while the control A group received etomidate anesthesia.Fentanyland rocuronium were administered to the two groups.All the children were given fentanyl to maintain anesthesia before operation.Another70healthy children were selected as the control B group.The cognitive function of the children in the B group and thecontrol group was evaluated1days before operation,3days after operation and3months after the operation.Results:The cognitivefunction scores of the observation group and the control group3days after operation were lower than1day before theoperation(P<0.05).The cognitive function scores and cognitive impairment after3months of operation in the two groups werecompared with those before operation,and the difference was not statistically significant(P>0.05).Conclusion:Anesthesia withpropofol or etomidate can induce different degrees of cognitive dysfunction in children,but it can be recovered within3monthsafter operation.