喹硫平合并无抽搐电休克治疗女性难治性精神分裂症的临床效果观察

Clinical Observation of Quetiapine combined with Non-convulsive Electrical Shock in the Treatment of Female Refractory Schizophrenia

目的研究喹硫平合并无抽搐电休克治疗女性难治性精神分裂症的临床疗效。方法将我院2014年11月至2016年2月期间所收治的84例女性难治性精神分裂症患者作为本次的研究对象,按照治疗方法的不同将其分为研究组和对照组,每组各42例,对照组应用喹硫平治疗,研究组在此基础上行无抽搐电休克治疗,对比分析两组患者的治疗效果、BPRS评分与不良反应发生情况。结果研究组患者的治疗总有效率显著高于对照组,且BPRS评分明显优于对照组,两组差异明显(P<0.05),统计学意义存在;在不良反应发生情况方面,两组无统计学意义(P>0.05)。结论喹硫平合并无抽搐电休克治疗女性难治性精神分裂症的效果明显,能够有效提高患者的治疗总有效率,促进患者早日康复,值得应用。

Objective To study the clinical efficacy of quetiapine combined with modified electroconvulsive therapy in the treatment of refractory schizophrenia.Methods In our hospital in November2014-February2016year,84cases of women were refractory schizophrenia patients as the research object,according to the different methods of treatment will be divided into study group and control group,42cases in each group,the control group using quetiapine treatment,study group based on no MECT,compared two groups of patients,BPRS score and adverse reaction.Results In the treatment of patients in the study group,the total effective rate was significantly higher than the control group,and the BPRS score was significantly better than the control group,the two groups have significant difference(P<0.05),there is statistical significance;situation occurred in adverse reactions,two groups had no statistical significance(P>0.05).Conclusion Quetiapine combined with modified electroconvulsive therapy is effective in the treatment of refractory schizophrenia.It can effectively improve the total effective rate of patients and promote the recovery of patients.