T2直肠癌肿瘤浸润深度与淋巴结转移的相关性研究

Study on correlation between tumor invasion depth and lymph node metastasis in T2 rectal cancer

目的明确T2直肠癌淋巴结转移的影响因素及浸润深度与淋巴结转移的相关性,给临床上局部切除术的选择提供依据。方法 200例T2直肠癌患者,通过单因素和多因素分析,确定淋巴结转移的危险因素,利用树形分析分析淋巴结转移的发生率。结果多因素回归分析中,年龄≤65岁、中低位肿瘤(≤8 cm)、存在低分化腺癌或粘液腺癌/印戒细胞癌、浸润深肌层(深T2)是T2直肠癌淋巴结转移的危险因素。树形分析中高位病理类型较好的患者淋巴结转移率为6.3%,中低位没有其他风险因素的患者淋巴结转移率为3.3%。结论浸润深度是淋巴结转移的危险因素,伴有低淋巴结转移风险的T2直肠癌患者适用于局部切除术。

Objective To clarify the influencing factors of lymph node metastasis and the correlation between invasion depth and lymph node metastasis in T2rectal cancer,so as to provide basis for the selection of local resection.Methods A total of200T2rectal cancer patients,and the risk factors for lymph node metastasis was determined by single factor and multivariate analysis.Tree analysis was used to analyze the incidence of lymph node metastasis.Results Multi factor regression analysis showed age≤65years,middle-lower tumor(≤8cm),poorly differentiated adenocarcinoma or mucinous adenocarcinoma/signet ring cell carcinoma,deep myometrial invasion(deep T2)are risk factors for T2lymph node metastasis in rectal cancer.Tree analysis showed the lymph node metastasis rate was6.3%in patients with high pathologic type and3.3%in middle-lower risk patients with no other risk factors.Conclusion Invasion depth is a risk factor for lymph node metastasis.T2rectal cancer patients with low lymph node metastasis risk are suitable for local excision.