期刊文献+

地西他滨联合CAG方案治疗骨髓增生异常综合征和急性髓系白血病的临床观察 被引量:7

下载PDF
导出
摘要 目的探讨地西他滨联合CAG方案治疗骨髓增生异常综合征(MDS)和急性髓系白血病的临床疗效。方法 42例骨髓增生异常综合征和急性髓系白血病患者,根据治疗方式不同分为对照组和试验组,各21例。对照组予以地西他滨展开治疗,试验组予以地西他滨协同CAG方案开展治疗,对比两组患者治疗效果。结果回访1~3年,对照组生存时长为(17.37±1.29)个月,有15例患者生存,总生存率为71.43%;试验组生存时长为(18.99±1.28)个月;有20例患者生存,总生存率为95.24%;试验组生存时长及总生存率均优于对照组,差异有统计学意义(P<0.05)。试验组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。治疗后,对照组社会功能评分为(77.99±12.76)分,心理功能评分为(78.25±13.91)分,身体功能评分为(79.32±15.64)分;试验组社会功能评分为(92.26±21.41)分,心理功能评分为(95.73±21.12)分,身体功能评分为(94.12±24.85)分;试验组各项生活质量评分均高于对照组,差异有统计学意义(P<0.05)。结论地西他滨治疗骨髓增生异常综合征和急性髓系白血病患者具备较优的成效,值得大力推行及使用。
出处 《中国现代药物应用》 2017年第17期130-131,共2页 Chinese Journal of Modern Drug Application
  • 相关文献

参考文献9

二级参考文献73

  • 1Lubbert M, Suciu S, Baila L, et al. Low-dose decitabine versus best supportive care in elderly patients with intermediate- or high- risk myelodysplastic syndrome (MDS) ineligible for intensive chemotherapy : final results of the randomized phase III study of the European Organisation for Research and Treatment of Cancer Leukemia Group and the German MDS Study Group. J Clin Oncol, 2011:29 ( 15 ) _. 1987 - 1996.
  • 2张之南,沈悌.血液学诊断及疗效标准.第3版,北京,科学出版社,2006.279-281.
  • 3Saba HI. Decitabine in the treatment of myelodysplastic syn- dromes. Ther Clin Risk Manag, 2007 ;3 (5) : 807 -817.
  • 4Qin T, Castoro R, E1 AS, et al. Mechanisms of resistance to decitabine in the myelodysplastic syndrome. PLoS One, 2011 ; 6 (8) : 23372 -23382.
  • 5Steensma DP, Baer MR, Slack JL, et al. Multicenter study of decitabine administered daily for 5 days every 4 weeks to adults with myelodysplastic syndromes: the alternative dosing for outpatient treaanent (ADOPT) trial. J Clin Oncol, 2009 ; 27 ( 23 ) : 3842 - 3848.
  • 6Borthakur G, Ahdab SE, Ravandi F, et al. Activity of decitabine in patients with myelodysplastic syndrome previously treated with azacitidine. Leuk Lymphoma,2008 ;49(4) : 690 - 695.
  • 7Santos FP, Kantarjian H, Garcia-Manero G, et al. Decitabine in the treatment of myelodysplastic syndromes. Expert Rev Anticancer Ther, 2010;10(1) : 9 -22.
  • 8Lee JH, Lee KH, Lee JH, et al. Decreased incidence of febrile episodes with antibiotic prophylaxis in the treatment of decitabine for myelodysplastic syndrome. Leuk Res, 2011 ; 35 (4) : 499 - 503.
  • 9Guo M, Hu KX, Yu CL, et al. Infusion of HLA-mismatched peripheral blood stem cells improves the outcome of chemotherapy for acute myeloid leukemia in elderly patients. Blood, 2011;117 (3) : 936 -941.
  • 10Santini V,Kantarjian HM,Issa JP.Changes in DNA methylation in neoplasia: pathophysiology and therapeutic implications[].Annals of Internal Medicine.2001

共引文献129

同被引文献48

引证文献7

二级引证文献10

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部