雷贝拉唑联合莫沙必利治疗反流性食管炎的临床效果

Clinical efficacy of rabeprazole plus mosapride on reflux esophagitis

目的:探讨雷贝拉唑联合莫沙必利治疗反流性食管炎的临床疗效。方法:筛选2014年1月-2015年1月我院收治的反流性食管炎患者80例作为研究对象。采用随机数表法将其分为观察组与对照组,每组40例,其中对照组患者单纯应用雷贝拉唑进行治疗,观察组在对照组的基础上加服莫沙必利治疗,比较两组患者临床疗效,并评价胃镜下治疗总有效率及治疗后不良反应发生情况。结果:观察组患者治疗显效21例,有效17例,治疗总有效率为95.0%,对照组显效16例,有效13例,治疗总有效率为72.5%,观察组治疗总有效率明显高于对照组(P<0.05);胃镜下观察组显效18例,有效16例,总有效率为85.0%,对照组显效12例,有效11例,总有效率为57.5%,观察组胃镜下总有效率明显高于对照组(P<0.05);两组患者不良反应发生率比较无显著差异(P>0.05)。结论:雷贝拉唑联合莫沙必利治疗反流性食管炎较单纯应用雷贝拉唑具有更高的临床疗效,并且应用安全性较高,具有临床应用价值。

Objective:To explore clinical efficacy of rabeprazole with mosapride on reflux esophagitis.Methods:80patients were divided into the observation group and control group,40patients in each group.The control group took rabeprazole;The observation group was treated with mosapride more.Results:In the observation group,21cases were effective;17cases were a little effective;the total efficiency was95.0%.In the control group,16cases were effective;13cases were a little effective;the total efficiency was72.5%.The total efficiency in the treatment group was significantly higher(P<0.05).In the observation group of endoscopy,18cases were effective;16cases were a little effective;the total efficiency was85.0%.In the control group of endoscopy,12cases were effective;11cases were a little effective;the total efficiency was57.5%.The total efficiency of endoscopy in the treatment group was significantly higher(P<0.05).There was no significant difference in adverse reactions between two groups(P>0.05).Conclusion:Rabeprazole with mosapride was effective on reflux esophagitis,with safety and clinical application value.