内皮型一氧化氮合成酶基因rs1799983多态与血压的关系

The Relationship between Endothelial Nitric Oxide Synthase rs1799983 Gene Polymorphism and Blood Pressure

目的:探讨内皮型一氧化氮合成酶rs1799983多态与血压的关系。方法:在大理邀请某工厂职工参与研究,运用问卷收集饮酒、吸烟、药物服用等信息,用SNa Pshot方法进行基因分型。结果:rs1799983多态GG、GT和TT频率分别为80.3%、19.0%和0.7%。基因型频率和等位基因频率在血压正常者和高血压患者间的差异没有统计学意义(P≥0.21)。在调整协变量前后,T等位基因携带者(GT+TT)的收缩压和脉压均显著高于GG纯合子(P≤0.04)。进一步分析发现,rs1799983多态和低密度脂蛋白胆固醇显著交互作用影响脉压(P_(int)=0.04)。随着低密度脂蛋白胆固醇水平升高,T等位基因携带者和GG纯合子相比,脉压显著升高。结论:内皮型一氧化氮合成酶rs1799983多态可能与血压相关,且受低密度脂蛋白胆固醇水平的影响。

Objective:To explore the relationship between endothelial nitric oxide synthase(eNOS)rs1799983polymorphism andblood pressure.Methods:All employees including the retired of a factory in Dali were enrolled in the study.A standardizedquestionnaire was distributed to collect information on alcohol consumption,smoking habits and use of medications.And then thegenotypes were categorized by SNaPshot method.Results:The frequencies of rs1799983GG,GT and TT were80.3%,19.0%and0.7%respectively.There was no significant difference in genotypes and alleles between participants with normal blood pressure andhypertensive patients(P≥0.21).However,T allele carriers(GT+TT)compared with GG homozygotes had a significantly highersystolic and pulse pressure both before and after adjusted for covariates(P≤0.04).It was found that significant interaction betweenrs1799983polymorphism and low-density lipoprotein cholesterol(LDL-C)had an effect on pulse pressure(Pint=0.04).Pulsepressure of T allele carrier was significantly higher than GG homozygotes as LDL-C levels increased.Conclusion:The eNOSrs1799983polymorphism may be associated with blood pressure and affected by LDL-C levels.