排毒尪痹汤对类风湿性关节炎患者T细胞亚群的影响

Effects of Wang-bi Detoxification Herbal Medication on T-lymphocyte Subgroups of Patients with Rheumatoid Arthritis

目的:观察排毒尪痹汤对类风湿性关节炎(RA)患者外周血T淋巴细胞亚群的影响,从细胞免疫方面探讨本方药的疗效机制。方法:使用随机且平行对照的方法,按随机数字表法将200例门诊及住院患者分为两组。对照组100例,吲哚美辛肠溶片25 mg/次,1次/d,甲氨蝶呤片7.5 mg/次,1次/周;治疗组100例,排毒尪痹汤煎服200 mL/次,2次/d。连续治疗4周为1疗程,两个疗程后,于治疗前和治疗后分别检测CD4^+,CD8^+细胞,计算CD4^+/CD8^+值。结果:治疗前两组CD4^+、CD8^+、CD4^+/CD8^+值比较差异无统计学意义(P>0.05)。治疗后,两组较治疗前,CD4^+细胞均下降,CD8^+细胞均升高,CD4^+/CD8^+比值均降低;且两组治疗后各指标组间比较差异无统计学意义(P>0.05)。结论:RA患者体内存在着细胞免疫功能紊乱,排毒尪痹汤能调节T细胞分布,使机体趋向免疫稳定状态,具有类似MTX联合用药的免疫抑制效应。

Objective:To observe effects of Wang-bi detoxification herbal medication on T-lymphocyte subgroups of patients withRheumatoid Arthritis,and to explore the mechanism of it efficacy.Methods:A comparative study was conducted among200patientsincluding inpatients and outpatients who were divided into two groups randomly.100patients in the control group took IndometacinEnteric-coated Tablets with25mg every time and once a day,and Methotrexate Tablets with7.5mg every time and once a week,while100patients in the treatment group took Wang-bi detoxification herbal medication with200mL each time and twice a day.After twocourses of eight weeks,we compared CD4+and CD8+of the two groups before and after the treatment.Results:There was nosignificant difference with regard to the comparison of CD4+and CD8+of each group before the treatment(P>0.05).However,afterthe treatment both of the groups had a lower CD4+and a higher CD8and a lower ratio of CD4+to CD8+.Comparison between the twogroups also showed no significant difference(P>0.05).Conclusion:Patients with RA has an autoimmune disorder.Wang-bidetoxification herbal medication can help the distribution of their T-lymphocyte subsets and help them keep a stable immune system,and can have a similar immunosuppressive effect as that produced by the therapy of MTX in combination with other medicines.