慢性乙肝病毒携带者ALT、AST及HBeAg与血清HBV DNA含量的关系

Relationship between ALT, AST, HBeAg and serum HBV DNA content in chronic hepatitis B virus carriers

目的探究慢性乙肝病毒(hepatitis B virus,HBV)携带丙氨酸氨基转移酶(alanine aminotransferase,ALT)、谷草转氨酶(aspertate aminotransferase,AST)及乙型肝炎E抗原(hepatitis B e antigen,HBeAg)与血清HBV DNA含量的关系。方法选取2013年9月-2017年3月我院收治的口腔疾病患者中63例慢性HBV携带患者与37例轻度乙型肝炎患者,检测其ALT、AST、HBeAg水平及血清HBV DNA载量,分析慢性HBV携带患者ALT、AST、HBeAg水平及血清HBV DNA载量之间的关系;将63例慢性HBV携带者按照HBV DNA载量分为3组,分析ALT、AST及HBeAg与HBV DNA不同载量的关系。结果慢性HBV携带患者ALT、AST与轻度乙型肝炎患者相比差异具有统计学意义(P<0.05),HBeAg^+发生率相比差异无统计学意义(P>0.05);ALT及AST水平随HBV DNA载量上升而升高,中拷贝与高拷贝ALT相比差异显著(P<0.05),AST相比差异无统计学意义(P>0.05);HBeAg^+患者数量随HBV DNA载量升高而变多,HBeAg-患者数量随HBV DNA上升整体呈下降趋势,HBeAg^+组中血清HBV DNA载量与HBeAg-组相比明显较多(P<0.05);ALT及HBeAg^+与HBV DNA载量呈正相关,AST与HBV DNA载量无明显相关性。结论慢性HBV携带患者的肝功能损害不明显,但病毒复制活跃,ALT可反映肝细胞损害程度,特异性较高,ALT及HBeAg与血清HBV DNA载量相关性良好,AST与血清HBV DNA无明显相关性。

Objective To explore the relationship between alanine aminotransferase(ALT),aspertateaminotransferase(AST),hepatitis B e antigen(HBeAg)and serum HBV DNA content in chronic hepatitis B virus(HBV)carriers.Methods From September2013to March2017,63cases of chronic HBV carriers and37cases ofmild hepatitis B patients with oral diseases from our hospital in September2013to March2017were selected.Thelevels of ALT,AST,HBeAg and serum HBV DNA load were tested.The relationship between ALT,AST,HBeAgand serum HBV DNA load of chronic HBV carriers were analyzed.The63chronic HBV carriers were divided intothree groups based on HBV DNA load,and the load relationship between ALT,AST,HBeAg and HBV DNA contentwere analyzed.Results The levels of ALT,AST of chronic HBV carriers had significant difference comparedto mild hepatitis B patients(P<0.05),and there was no statistical significant difference compared to the incidence ofHBeAg+(P>0.05).ALT and AST level rised with the HBV DNA load.The difference of ALT between the mid-copyand high-copy patients was significant(P<0.05),and there was no statistical difference of AST between mid-copyand high-copy patients(P>0.05).The number of HBeAg+patients increased with the increase of HBV DNA load,and the number of HBeAg-patients decreased with the increase of HBV DNA load.The serum HBV DNA load ingroup HBeAg+was significantly higher than that in group HBeAg-(P<0.05).ALT and HBeAg+were positively correlatedwith HBV DNA load.There was no significant correlation between AST and HBV DNA load.ConclusionThe impairment of liver function in patients with chronic HBV is not obvious,but the replication of virus is active,and ALT can reflect the degree of liver cell damage,and the specificity is higher.ALT and HBeAg had correlationwith serum HBV DNA load,and there was no significant correlation between AST and serum HBV DNA.