异甘草酸镁联合头孢哌酮舒巴坦钠治疗重型肝炎合并胆道感染的疗效

Efficacy of magnesium isoglycyrrhizinate combined with cefoperazone sulbactam sodium on severe hepatitis with biliary tract infection

目的探究异甘草酸镁联合头孢哌酮舒巴坦钠治疗重型肝炎合并胆道感染的疗效。方法选取我院2014年8月-2016年8月收治的80例重型肝炎合并胆道感染患者,对其病历资料进行回顾性分析,将接受异甘草酸镁联合头孢哌酮舒巴坦钠治疗的40例患者设为观察组,接受复方甘草酸苷联合头孢哌酮舒巴坦钠治疗的40例患者设为对照组。比较两组患者肝炎以及胆道感染疗效,并进行血常规及肝功能检查。结果观察组重型肝炎治疗总有效率为95.0%,显著高于对照组(77.5%),差异有统计学意义(P<0.05);观察组胆道感染治疗总有效率为92.5%,与对照组(72.5%)有明显差异(P<0.05);两组患者治疗前后白细胞(white blood cell,WBC)、中性粒细胞(neutrophilicgranulocyte,NE)均显著降低,但组间差异无统计学意义(P>0.05);两组患者治疗前后谷丙转氨酶(alanine transaminase,ALT)、谷草转氨酶(glutamic oxaloacetic transaminase,AST)、谷氨酰转移酶(glutamvl transferase,GGT)以及血清总胆红素(total bilirubin,TBil)差异显著,且治疗后观察组显著低于对照组,差异有统计学意义(P<0.05)。结论异甘草酸镁联合头孢哌酮舒巴坦钠治疗重型肝炎合并胆道感染能够显著改善肝炎症状,病原菌清除效果良好,相较于复方甘草酸苷更能显著提升肝功能。

Objective To explore the efficacy of magnesium isoglycyrrhizinate combined with cefoperazonesulbactam sodium on severe hepatitis with biliary tract infection.Methods80cases of patients with severehepatitis with biliary tract infection admitted in our hospital since August2014to August2016were selected as thesubjects,and the case data of these patients were analyzed retrospectively.40cases treated with magnesium isoglycyrrhizinatecombined with cefoperazone sulbactam sodium were set as the observation group,while the other40cases treated with compound glycyrrhizin combined with cefoperazone sulbactam sodium were set as the controlgroup.The efficacy between the two groups were compared.Results The overall treatment efficacy of severehepatitis in the observation group was95.0%,which was significantly higher than that of the control group(77.5%),with statistical significance(P<0.05).The overall treatment efficacy of infection of biliary tract in the observationgroup was92.5%,which had significant difference(P<0.05)from that in the control group(72.5%).After treatment,the white blood cell(WBC)and neutrophil(NE)of patients in both groups decreased dramatically compared withbefore treatment,and there was no significant difference between observation group and control group(P>0.05).There was significant difference in alanine transaminase(ALT),aspartate transaminase(AST),glutamine glutamyltransferase(GGT)and total bilirubin in serum(TBil)of patients in both groups before and after treatment,and aftertreatment,those in the observation group were significantly lower than those in the control group,with statisticalsignificances(P<0.05).Conclusion Magnesium isoglycyrrhizinate combined with cefoperazone sulbactam sodiumcan distinctly improve symptoms of hepatitis in treating severe hepatitis with biliary tract infection,with goodclearance of pathogenic bacteria,which performs better than compound glycyrrhizin in improving liver function.