四君子汤与四君子丸干预脾气虚大鼠宏观表征的比较研究

Comparation of sijunzi decotion and sijunzi pill treating macroscopic tokens of rats in spleen qi deficiency

目的从体质量、进食水量、肌力和神志方面比较四君子汤和四君子丸的药效学差异。方法 32只SPF级雄性SD大鼠,随机分为对照组、脾气虚组(模型组),四君子丸组(丸剂组)和四君子汤组(汤剂组),每组8只;电子天平检测大鼠体质量;代谢笼计量24 h进食水量;大小鼠抓力测定仪测量前肢抓力;旷场实验评价大鼠的神志状态。结果与对照组相比,模型组的体质量、进食水量、前肢抓力、运动距离、站立次数和角落停留时间等均显著减少(P<0.05),但中心和周边停留时间明显延长,而后两组的体质量和进水量均显著下降,但进食量显著上升(P<0.05)。与模型组比较,后两组的体质量、进食量、前肢抓力、运动距离、站立次数和角落停留时间均显著上升(P<0.05),中心和周边活动时间显著缩短,但丸剂组饮水量明显减少(P<0.05);与丸剂组比较,汤剂组的饮水量和运动距离均显著增加(P<0.05)。结论四君子汤与四君子丸均有较好的健脾益气作用,但汤剂在促进饮水和安神益志方面的疗效优于丸剂。

Objective To study the pharmacological difference of sijunzi decotion and sijunzi pill in food and water intakes,muscle strength andconsciousness.Methods32male SPF SD rats were randomly divided into four groups,the control,spleen qi deficiency group(model group),sijunzipill group(pill group)and sijunzi decotion(decotion group),8each group.Rat body mass was measured by the electronic balance,food and waterintakes per24h were detected in the metabolic cage,forelimb grip strength was tested by the grip strength instrument for rats and mice,and consciousnesswas valuated with the open field method.Results Compared with those in the control group,values of body mass,food and water intakens,forelimb grasp strength,motion distance,standing times and corner residence time were all increased(P<0.05),but middle and peripheral residencetime were decreased,significantly,in the model group,while body mass and water intaken were reduced obviously in later2groups(P<0.05).Compared with those in the model group,there were significantly increased in the body mass,forelimb grasp strength,motion distance,standingtimes and corner residence time,and decreased in middle and peripheral residence time,for later2groups,while water intaken was reduced obviouslyin the pill group(P<0.05);compared with those in the pill group,water intaken and motion distance in the decotion group were increased significantly(P<0.05).Conclusion Both sijunzi decotion and sijunzi pill have the invigoration of spleen qi,but the former has better effects on promotionof water intake and thought than the later.