摘要
目的探讨拉莫三嗪在难治性癫痫患者中治疗效果及安全性。方法选取难治性癫痫患者74例为研究对象,采用信封分组法将患者分为研究组和对照组,分别加用拉莫三嗪和安慰剂治疗,比较两组患者临床疗效和药物不良反应发生情况。结果研究组患者治疗总有效率显著高于对照组(89.19%vs 62.16%)(P<0.05)。两组患者头晕头痛、记忆力下降、焦虑、乏力、脱发、流涎、盗汗药物不良反应发生率比较无统计学意义。结论拉莫三嗪在难治性癫痫患者中治疗可提高患者临床疗效,并不增加药物不良反应,具有显著临床疗效和治疗安全性。
Objective To investigate the therapeutic effect and safety of lamotrigine in patients with refractory epilepsy.Methods Select74case of refractory epilepsy as studying object,divide them to study group and control group,respectively,with lamotrigine and placebo treatment,compare the two groups of patients in clinical efficacy and adverse drug reactions.Results The total effective rate of treatment in the study groupwas significantly higher than that in the control group(89.19%vs62.16%)(P<0.05).There was no statistically significant difference in the incidenceof adverse reactions between dizziness and headache,memory loss,anxiety,fatigue,hair loss,salivation and sweating.Conclusion Lamotriginetreatment in patients with refractory epilepsy can improve the clinical efficacy of patients,does not increase the adverse drug reactions,with significantclinical efficacy and treatment safety.
作者
何兵荣
He Bing-rong(The People Hospital of Shang Li district, Ping Xiang city, Jiang Xi province, No.3 Medicine Department, Pingxiang, Jiangxi,337009, China)
出处
《当代医学》
2017年第26期63-64,共2页
Contemporary Medicine