曲美他嗪、阿托伐他汀钙、心理干预联用治疗冠心病心绞痛伴血脂异常的临床研究

Clinical study of trimetazidine combined with atorvastatin calcium and psychological intervention in the treatment of coronary heart disease with angina pectoris and dyslipidemia

目的为提高冠心病心绞痛伴血脂异常患者的临床疗效，分析联合应用曲美他嗪、阿托伐他汀钙、心理干预的临床价值。方法选取本院内科收治冠心病心绞痛伴血脂异常患者86例，按照随机数字表法分为对照组和研究组，每组43例。对照组患者给予常规冠心病心绞痛伴血脂异常对症治疗加口服盐酸曲美他嗪，研究组在对照组的基础上给予口服阿托伐他汀钙加心理干预治疗。结果治疗后研究组和对照组患者临床有效率分别为95.34%和81.4%，组间差异具有统计学意义（P＜0.05）；研究组患者SDS、SAS评分优于对照组，组间差异具有统计学意义（P＜0.05）；研究组患者TC、TG、LDL-C水平明显低于对照组，HDL-C水平高于对照组，组间差异具有统计学意义（P＜0.05）；研究组患者心绞痛发作次数少于对照组，发作持续时间比对照组短，组间差异具有统计学意义（P＜0.05）。结论曲美他嗪、阿托伐他汀钙、心理干预联用对于治疗冠心病心绞痛伴血脂异常，临床有效率由81.4%提升到95.34%，降低了患者抑郁、焦虑等不良情绪，使血脂得到有效控制，改善患者临床症状，减轻患者病痛，具有较高临床应用价值。

Objective To improve the clinical efficacy of angina pectoris with dyslipidemia patients,analysis of the combined use oftrimetazidine,atorvastatin calcium,the clinical value of psychological intervention.Methods86cases of patients with coronary heart disease andangina pectoris with dyslipidemia were selected,according to the random number table method is divided into control group and study group,eachgroup of43cases.The control group were given routine symptomatic angina pectoris of coronary heart disease with abnormal blood lipid therapyplus trimetazidine hydrochloride oral Sibutramine,study group on the basis of the control group given oral atorvastatin calcium plus psychologicalintervention of statin treatment.Results After treatment,the clinical efficiency of the study group and the control group was95.34%and81.4%,the difference between the two groups was statistically significant(P<0.05);patients in the study group SDS,SAS score than the control group,thedifference between the two groups was statistically significant(P<0.05);patients in the study group,TC,TG,LDL and C levels were significantlylower than the control group,the HDL level of C higher than that of control group,the difference between the two groups was statistically significant(P<0.05);study on patients with angina pectoris attack times less than the control group,the seizure duration shorter than the control group,thedifference between the two groups was statistically significant(P<0.05).Conclusion Psychological intervention combined with the treatment ofangina pectoris of coronary heart disease with abnormal blood lipid,clinical efficiency increased from81.4%to95.34%,reduced in patients withdepression,anxiety and other negative emotions,so that the blood has been effectively controlled,improve clinical symptoms,reduce the pain ofpatients,with high clinical value.