反流性食管炎应用雷贝拉唑联合莫沙必利方案治疗的价值及效果评价

Value and effect evaluation of Rabeprazole Combined with Mosapride in the Treatment of Reflux Esophagitis

目的探讨反流性食管炎应用雷贝拉唑联合莫沙必利方案治疗的效果。方法利用计算机随机选取的的方式，将浙江省湖州市双林人民医院2016年4月～2017年4月收治的反流性食管炎患者92例，均分为研究组和常规组（n=46）。常规组采用奥美拉唑与莫沙必利进行治疗，研究组采用雷贝拉唑与莫沙必利进行治疗，观察并比较2组临床疗效以及不良反应。结果研究组治疗总有效率为91.30%高于常规组76.09%，差异有统计学意义（P＜0.05）。研究组反流症状，食管刺激症状，食管外刺激症状的总有效率明显高于常规组（P＜0.05）。研究组不良反应率为4.35%，常规组为6.52%，差异无统计学意义。结论反流性食管炎在进行临床治疗过程中，应当重视抑酸、胃动力两个方面。其中在抑酸方面雷贝拉唑的药效要明显高于奥美拉唑。在胃动力方面，莫沙必利在临床的效果也较优。反流性食管炎应用雷贝拉唑联合莫沙必利治疗，临床疗效显著，且不良反应率低，安全可靠，值得临床应用。

Objective To investigate the efficacy of rabeprazole combined with mosapride in the treatment of reflux esophagitis.Methods Atotal of92patients with reflux esophagitis admitted from April2016to April2017in our hospital were divided into study group and routine group(n=46).The routine group was treated with omeprazole and Mosapride,the study group was treated with rabeprazole and mosapride.The clinicalefficacy and adverse reactions in the two groups were observed and compared.Results The total effective rate was91.30%in the study group and76.09%in the conventional group,the difference was statistically significant(P<0.05).The total effective rate of reflux symptoms,esophagealirritation and esophageal irritation was significantly higher in the study group than in the conventional group(P<0.05)The adverse reaction rate was4.35%in the study group and6.52%in the conventional group,the difference was not statistically significant(P<0.05).Conclusion In the courseof clinical treatment of reflux esophagitis,attention should be paid to the two aspects of acid suppression and gastric motility.In the inhibition ofacid,the effect of Bella is obviously higher than that of omeprazole.In gastric motility,mosapride in clinical effect is better.Reflux esophagitis byrabeprazole combined with mosapride treatment,clinical efficacy is significant,and adverse reaction rate is low,safe and reliable,worthy of clinicalapplication.