替米沙坦对原发性高血压患者血清脂联素、内皮细胞分化功能和颈动脉粥样硬化的影响

Effects of telmisartan on serum adiponectin,endothelial cell differentiation and carotid atherosclerosis in patients with essential hypertension

目的探讨替米沙坦对原发性高血压患者血清脂联素、内皮细胞分化功能和颈动脉粥样硬化的影响。方法选取2012年4月～2016年9月汉中市中心医院心内科住院并确诊的126例原发性高血压患者，随机分成常规组（n=61）及替米沙坦组（n=65），替米沙坦组予复方替米沙坦；常规组予复方氯沙坦。治疗结束后，测定患者血压、脂联素、一氧化氮、内皮素、颈动脉内膜-中层厚度水平。结果替米沙坦组收缩压、舒张压略高于常规组；替米沙坦组ADPN、NO水平高于常规组，EL、IMT低于常规组（P<0.05）；替米沙坦组的有效率高于常规组（P<0.05）。结论替米沙坦能有效控制并降低制原发性高血压患者的血压、修复血管内皮分化功能，抑制动脉粥样硬化进展。

Objective To investigate the effect of telmisartan on serum adiponectin,endothelial cell differentiation and carotid atherosclerosisin patients with essential hypertension.Methods A total of126patients with essential hypertension enrolled in our hospital from April2012toSeptember2016were randomly divided into the conventional group(n=61)and telmisartan group(n=65),telmisartan group was given compoundtelmisartan;Conventional group was treated with compound losartan.After treatment,blood pressure,adiponectin,nitric oxide,endothelin andcarotid intima-media thickness were measured.Results The systolic blood pressure and diastolic blood pressure of telmisartan group were slightlyhigher than those in the conventional group;The levels of ADPN and NO in the telmisartan group were higher than those in the conventional group,while the EL and IMT were lower than those in the conventional group(P<0.05).The effective rate of telmisartan group was higher than that of theconventional group(P<0.05).Conclusion Telmisartan can effectively control and reduce the blood pressure in patients with essential hypertension,repair vascular endothelial differentiation and inhibit the progression of atherosclerosis.