干细胞治疗缺血性脑卒中的抗炎效应

Anti-inflammatory effect of stem cells in the treatment of ischemic stroke

背景:基础实验已表明,干细胞具有免疫正调节能力和细胞替代功能。目的:总结干细胞移植治疗缺血性脑卒的抗炎效应,在此基础上进一步讨论其具体的机制。方法:以"stem cells,stroke,inflammation,immune"为关键词,应用计算机检索2012至2017年PubMed、Elsevier、Springer、Wiley、ovid、EBSCO等数据库中的文献,共搜索到文献110篇,最终纳入47篇文献。结果与结论:神经干细胞、间充质干细胞、内皮组细胞等干细胞移植治疗缺血性脑卒的抗炎效应,主要包括减少局灶性炎症反应,免疫调节,促进多种神经营养因子的分泌,减少继发性细胞死亡,保护神经元,促进细胞功能恢复进而促进神经功能的恢复。干细胞的局部免疫调节和抑炎作用主要体现在其分泌因子作用于巨噬细胞,使其发生M1到M2型转化,干预免疫分泌的细胞因子图谱,并对胶质细胞进行抑制和极化等。干细胞移植治疗脑卒中的抗炎效应和免疫调节功能亟需深入的研究。

BACKGROUND:A large number of preclinical experimental data have shown that stem cells can regulate the immune function,and serve the function of cell replacement.OBJECTIVE:To summarize the anti-inflammatory effects of stem cells in the treatment of ischemic stroke,based on which,we further discuss the specific mechanisms.METHODS:We conducted a systematic and comprehensive search in PubMed,Elsevier,Springer,Wiley,Ovid,EBSCO databases.The range of retrieval time was from2012to2017.The keywords were“stem cells,stroke,inflammation,immune”.Totally110articles were retrieved initially,and47articles were included in result analysis.RESULTS AND CONCLUSION:By reading extensive literature,we analyzed and summarized the research status quo of the anti-inflammatory effects of neural stem cells,mesenchymal stem cells and endothelial cells in the treatment of ischemic stroke.The mechanisms mainly include reducing focal inflammation,immune regulation,promoting the secretion of various neurotrophic factors,reducing secondary cell death,protecting neurons and promoting cell function recovery and further promoting the recovery of nerve function.The mechanisms underlying local immune regulation and anti-inflammatory effects of stem cells are mainly described as the shift from M1to M2macrophages under the intervention of stem cell factors,to intervene secreted immune cytokine profiles and exert effects on inhibition and polarization of glial cells.Further investigation is required on the anti-inflammatory effects and immune regulation of stem cell therapy for stroke.