针刺联合背俞穴埋线治疗变应性鼻炎临床研究

Clinical Study on Acupuncture Combined with Back Shu Acupoint Catgut Embedding Therapy in Treating Allergic Rhinitis

目的观察针刺联合背俞穴埋线治疗变应性鼻炎的临床疗效。方法纳入变应性鼻炎患者66例,采用随机数字表法分为观察组和对照组各33例。对照组予富马酸酮替芬滴鼻液,每次2滴,每日3次,滴鼻;氯雷他定片,每次10 mg,每日1次,口服。连续治疗4周。观察组予针刺每日1次,10次为1个疗程,共治疗3个疗程;同时予双侧背俞穴埋线,15 d治疗1次,共治疗2次。观察2组患者临床疗效、症状评分、生活质量评分、血清炎性因子水平、血清免疫球蛋白E(Ig E)、外周血嗜酸性粒细胞(EOS)及不良反应情况。结果观察组总有效率为93.94%(31/33),对照组为75.76%(25/33),2组比较差异有统计学意义(P<0.05)。与治疗前比较,2组鼻症状总积分表(TNSS)评分、鼻炎伴随症状总分表(TNNSS)评分及鼻结膜炎生命质量调查问卷(RQLQ)评分显著降低(P<0.05),Ig E、EOS、血清白细胞介素(IL)-17及IL-22水平显著降低(P<0.05)。与对照组比较,治疗组治疗后TNSS、TNNSS、RQLQ评分及Ig E、EOS、IL-17、IL-22水平均低于对照组(P<0.05)。2组不良反应比较差异无统计学意义(P>0.05)。结论针刺联合背俞穴埋线治疗变应性鼻炎的临床疗效显著,能改善患者炎性因子水平,安全性较高。

Objective To investigate the clinical efficacy of acupuncture combined with back Shu acupoint catgut embedding therapy in treating allergic rhinitis.Methods Totally66allergic rhinitis patients were included.Random number table method was used to divide the66patients into observation group and control group,with33cases in each group.The control group was given Ketotifen Fumarate Nasal Drops nose drops2drops each time,3times a day,Loratadine Tablets10mg orally,once a day for4weeks.The experimental group was treated with acupuncture,once a day,10d as a treatment course,three courses in total;at the same time,back Shu acupoint catgut embedding therapy was given,15d each time,twice treatment in total.After the end of treatment,clinical efficacy,clinical symptom score,life quality score,serum levels of inflammatory factors,serum immunoglobulin,peripheral blood eosinophil count and the incidence of adverse reactionsof the two groups were observed.Results The total effective rate was93.94%(31/33)in observation group and75.76%(25/33)in the control group,with statistical significance in the two groups(P<0.05).Compared with before treatment,the TNSS score,TNNSS score and RQLQ score of the two groups were significantly lower than after treatment(P<0.05);the IgE and EOS levels significantly decreased(P<0.05);the serum IL-17and IL-22levels were significantly lower(P<0.05).Compared with the control group,the TNSS,TNNSS and RQLQ score and the levels of IgE,EOS,IL-17and IL-22in the treatment group were lower after treatment(P<0.05).There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion Acupuncture combined with catgut embedding therapy in the treatment of allergic rhinitis has a significant clinical efficacy,which can improve the level of inflammatory factors in patients with high safety.