命门八阵推拿联合赖氨葡锌颗粒治疗小儿慢性腹泻临床研究

Clinical Study on Mingmen Eight Array Massage Combined with Compound Lysine Hydrochloride and Zinc Gluconic Granules for Treatment of Infantile Diarrhea

目的观察命门八阵推拿联合赖氨葡锌治疗小儿慢性腹泻的临床疗效。方法纳入小儿慢性腹泻患者120例,采用随机数字表法分为治疗组、西药组和常规推拿组,每组40例。3组均予饮食指导,适量运动。西药组予赖氨葡锌颗粒,1~10岁每日2袋,>10岁每日3袋,口服。治疗组在西药基础上予命门八阵推拿。常规推拿组在西药基础上予常规推拿。均治疗4周。观察3组患者治疗前后唾液淀粉酶、血锌值、尿D-木糖吸收排泄率、中医症状积分,评价临床疗效。结果 3组患儿治疗后唾液淀粉酶、血锌值、尿D-木糖吸收排泄率水平与治疗前比较差异有统计学意义(P<0.05),治疗后治疗组唾液淀粉酶、血锌值、尿D-木糖吸收排泄率高于西药组及常规推拿组(P<0.05)。3组泄泻、便稀、神疲、面色少华、食量减少评分与治疗前比较均降低(P<0.05),治疗后,治疗组各项评分均低于西药组及常规推拿组(P<0.05)。治疗组、西药组和常规推拿组总有效率分别为92.50%(37/40)、72.50%(29/40)、75.00%(30/40),治疗组与西药组和常规推拿组比较差异有统计学意义(P<0.05)。结论命门八阵推拿联合赖氨葡锌颗粒可有效缓解小儿慢性腹泻患者临床症状,改善实验室指标。

Objective To observe the clinical efficacy of the Mingmen eight array massage combined with compound lysine hydrochloride and zinc gluconate granules for the treatment of infantile diarrhea.Methods Totally120children with diarrhea met the inclusion criteria were divided into the treatment group,Western medicine group,and general massage group by random number table method,40cases in each group.All3groups were given dietary guidance and did moderate exercise.Western medicine group was administered orally for compound lysine hydrochloride and zinc gluconate granules,two bags per day for the aged1-10,three bags per day for the aged>10.Treatment group was given the Mingmen eight array massage therapy based on Western medicine.General massage group received conventional massage therapy based on Western medicine,with four weeks as treatment course.3groups of patients were observed before and after treatment for salivary amylase,blood zinc value,urine D-xylose absorption and excretion test,TCM symptom score,and clinical efficacy were evaluated.Results There was statistical significance in the salivary amylase,blood zinc value,and urinary D-xylose absorption and excretion rate between before and after t reatment(P<0.05);after treatment,treatment group showed higher salivary amylase,blood zinc value,and urinary D-xylose absorption and excretion rate than the Western medicine group and general massage group(P<0.05);scores of diarrhea,loose stool,lassitude,lusterless complexion,and appetite reduction decreased compared with before treatment(P<0.05);after treatment,all integrals of treatment group were lower than Western medicine group and general massage group(P<0.05).The total effective rates of the treatment group,Western medicine group and general massage group were92.50%(37/40),72.50%(29/40),and75%(30/40)respectively.There was statistical significance among the three groups(P<0.05).Conclusion Mingmen eight array massage combined with compound lysine hydrochloride and zinc gluconic granules can effectively alleviate the clinical symptoms of patients with infantile diarrhea,and improve the level of laboratory parameters.