细辛炮制历史沿革和研究进展

History and Research Progress of Asari Radix et Rhizoma Processing

本文以《历代中药炮制资料辑要》为线索,结合历年版《中华人民共和国药典》、1988年版《全国中药炮制规范》、地方炮制规范及现代炮制研究相关资料,对古今文献收载的细辛炮制相关的内容进行归纳整理。历代关于细辛的炮制方法有净制、切制、加热炮制及加辅料炮制等记载,而现代细辛的炮制方法相对单一,除2008年版《上海市中药饮片炮制规范》收载的蜜炙外,各版《中华人民共和国药典》及其他规范仅提及净制和切制。近年研究表明,炒制、碱制、酒制、低温超微粉碎等炮制方法可有效降低细辛毒性,增强临床应用安全性。本文通过整理细辛炮制的历史沿革和研究进展,为现代炮制研究提供参考。

Setting Li Dai Zhong Yao Pao Zhi Zi Liao Ji Yao as clue,this article searched each edition of China Pharmacopoeia,National Processing Standard of Traditional Chinese Medicine issued in1988,and relevant materials of local processing standards and modern processing study,and concluded and combed the contents about Asari Radix et Rhizoma processing in ancient and modern literature.There are records about Asari Radix et Rhizoma processing methods in history,including net processing,cutting processing,heating processing and processing excipient.However,Asari Radix et Rhizoma processing methods in modern time are relatively simple.In addition to the version of the Processing Standard of Traditional Chinese Medicines in Shanghai issued in2008,containing the honey Asari Radix et Rhizoma,other editions of China Pharmacopoeia and processing standards only recorded net processing and cutting processing.Recent research showed that processing methods of modern stir frying processing,alkali processing,wine processing,low temperature ultrafine comminution processing and so on,can effectively reduce the toxicity of Asari Radix et Rhizoma and enhance the safety of clinical application.This article summarized the history and research progress of Asari Radix et Rhizoma processing,and provided a reference for the study on modern processing.