女性慢性乙型肝炎患者血清性激素变化特点及影响因素

Characteristics and influencing factors of serum sex hormones in female patients with chronic hepatitis B

目的探讨女性慢性乙型肝炎患者血清性激素的变化特点及影响。方法收集本院收治的慢性乙型肝炎患者(肝炎组)和健康女性(对照组)各30例,采用微粒子化学发光法测定其血清中促卵泡生成素(FSH)、黄体生成素(LH)、雌二醇(E2)、孕酮(P)、睾酮(T)和催乳素(PRL),对两组的性激素水平和绝经比例进行比较。结果与对照组相比,肝炎组患者血清中FSH和T水平显著升高,差异均具有统计学意义(t=-2.119、P=0.038,t=-2.312、P=0.024);肝炎组患者E2水平显著降低,差异具有统计学意义(t=2.542、P=0.014);两组患者血清中LH、PRL和P水平差异均无统计学意义(P均>0.05)。肝炎组患者的绝经比例显著高于对照组(χ~2=4.3886、P=0.0362)。结论慢性乙型肝炎可致女性患者血清中FSH和T升高、E2降低、绝经提前。

Objective To investigate characteristics and influencing factors of serum sex hormones in female patients with chronic hepatitis B.Methods Chronic hepatitis B patients(hepatitis group)and healthy women(control group)with30cases were collected in our hospital.Follicle stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E2),and progesterone(P),testosterone(T)and prolactin(PRL)in serum were measured by chemiluminescent immunoassay,and the levels of sex hormones and proportion of menopause were compared between the two groups.Results Compared with the group C,the levels of FSH and T in patients of CHB group were significantly increased,with significant differences(t=-2.119,P=0.038;t=-2.312,P=0.024),and E2in patients of CHB group decreased significantly,with significant difference(t=2.54,P=0.014).The levels of LH,P and PRL in patients of the two group were without significant differences(all P>0.05).The proportion of menopause of patients in CHB group was significantly higher than that of the control group(χ2=4.3886,P=0.0362).Conclusion Chronic hepatitis B ao lead the increase of levels of FSH and T in the serum of female patients,and the decrease of E2,and early menopause.