假体隆乳术后包膜挛缩发病机制及预防的研究进展

Research Progress of the Pathogensis and Prevention about Capsular Contracture after Implant-based Mammoplasty Augmentation

包膜挛缩是假体隆乳术后最常见的并发症,也是再次手术最常见的原因之一。因此了解包膜挛缩的发病机制及预防措施至关重要。多项研究认为假体表面材料类型、切口选择、血肿发生、引流充分与否、假体放置层次等均与包膜挛缩的发生相关,但这些结果仅源于临床观察,都缺乏实验数据的支撑。本文旨在从细菌感染、细胞分化、免疫与信号传导几个方面阐释包膜挛缩的发病机制,总结与发病机制相关的预防措施。现将包膜挛缩发病机制及预防的最新研究进展进行总结。

Capsular contracture is the most common sequel after implant-based mammoplasty augmentation,and one of the most common reason for reoperation.It is important to know the pathogensis and prevention about capsular contracture.Some study suggest that the surface texture of the implant、incision choice、hematoma、using of surgical drains、placed level etc which are associated with the incidence of capsular contracture,but lacking the biomolecular basis underlying their effectiveness.The article explore the pathogenesis of capsular contracture through the following several aspects:bacterial infections,cell differentiation,immunology and signal transduction,then summarise the corresponding preventive measures.The new progress of pathogenesis and preventionabout capsular contracture was reviewed in this literature review.