孟鲁司特联合氨溴特罗治疗老年咳嗽变异性哮喘的疗效观察

Efficacy of Montelukast Combined With Ambroxol Hydrochloride and Clenbuterol Hydrochloride in the Treatment of Senile Cough Variant Asthma

目的总结孟鲁司特联合氨溴特罗治疗老年咳嗽变异性哮喘的临床疗效。方法选取笔者所在医院2015年2月—2017年2月收治的老年咳嗽变异性哮喘患者共100例,所有患者随机分组,每组50例。两组患者均给予一般的干预措施,包括生活、饮食、起居等方面,药物治疗方面,两组患者均给予孟鲁司特钠,对照组患者另外给予茶碱缓释片,观察组患者给予氨溴特罗片,两组患者治疗两周后评价疗效。结果观察组患者临床总有效率为92%,高于对照组患者的68%,差异有统计学意义(χ~2=5.49,P<0.05),对照组患者出现消化道反应有4例,出现睡眠障碍有3例,不良反应发生率14%;观察组患者出现皮疹1例,睡眠障碍0例,不良反应发生率2%;对照组低于观察组,差异有统计学意义(χ~2=4.89,P<0.05)。结论孟鲁司特联合氨溴特罗治疗老年咳嗽变异性哮喘的临床疗效满意。

Objective To summarize the clinical efficacy of montelukast combined with ambroxol hydrochloride and clenbuterol hydrochloride in the treatment of senile cough variant asthma.Methods A total of100patients with senile cough variant asthma were enrolled in this study from February2015to February2017.All patients were randomized grouped,50patients in each group.Two groups of patients were given general intervention measures,including life,diet,living,etc.,drug treatment,the two groups were given montelukast sodium,patients in the control group were given theophylline sustained release tablets,patients in observation group were given ambroxol hydrochloride and clenbuterol hydrochloride.The curative effect was evaluated in the two groups after two weeks.Results The total effective rate was92%in the observation group,which was significantly higher than that in the control group(68%)(χ2=5.49,P<0.05).There were4cases of gastrointestinal reaction in the control group and3cases of dyspepsia,the incidence of reaction was14%.There was1case of rash in the observation group,0case of sleep disorder and2%of adverse reaction.The control group was significantly lowerthan the observation group(χ2=4.89,P<0.05).Conclusion The clinical efficacy of montelukast combined with ambroxol hydrochloride and clenbuterol hydrochloride in the treatment of senile cough variant asthma is satisfactory.