硫辛酸在脑梗死rtPA溶栓后的疗效观察

The effect of lipoic acid on rtPA thrombolysis after cerebral infarction

目的探讨硫辛酸用于重组组织型纤溶酶原激活剂(rtPA)静脉溶栓治疗后的治疗效果。方法选择2015年1月~2016年10月期间在本院行rt PA溶栓治疗的64例脑梗死患者作为研究对象,随机分为对照组和观察组,各32例。对照组患者常规行rtPA静脉溶栓治疗,观察组在对照组基础上增加硫辛酸治疗,观察两组患者临床疗效,并监测两组神经功能缺损改善情况。结果观察组临床治疗总有效率为90.63%(29/32),显著高于对照组78.13%(25/32),组间差异具有统计学意义(P<0.05)。两组均未见明显不良反应。治疗后,观察组NIHSS评分[(7.25±5.69)分]显著低于对照组[(9.14±6.14)分],组间比较差异具有统计学意义(P<0.05)。结论脑梗死rt PA溶栓后采用硫辛酸治疗可有效提升患者临床疗效,改善神经功能缺损程度良好,有助于改善患者预后,值得推广借鉴。

Objective To investigate the effect of lipoic acid on intravenous thrombolysis with recombinant tissue type plasminogen activator(rt-PA).Methods64Patients with cerebral infarction who were treated with thrombolytic therapy in our hospital from January2015to October2016were randomly divided into control group and observation group,each with a total of32Patients(rtPA).Patients in the control group were treated with intravenous thrombolysis with rtPA,while the observation group was treated with lipoic acid on the basis of the control group.The clinical efficacy of the two groups were observed,and the improvement of neurological deficit was observed in the two groups.Results The total effective rate of the observation group was90.63%(29/32),which was significantly higher than that of the control group78.13%(25/32),and the difference between the two groups was significant(P<0.05).There were no obvious adverse reactions in the two groups.After treatment,the NIHSS score of the observation group[(7.25±5.69)scores]was significantly lower than that of the control group[(9.14±6.14)scores],The differences between groups was statistically significant(P<0.05).Conclusion The use of lipoic acid in the treatment of cerebral infarction after rtPAthrombolysis can effectively improve the clinical efficacy of PAtients,improve the degree of neurological deficits,and help to improve the prognosis of PAtients,it is worth promoting.