透明质酸酶在口腔鳞癌组织中的表达及其临床意义

The analysis of expression of HAase in oral squamous cell carcinoma

目的探讨口腔鳞癌组织中透明质酸酶(hyaluronidase,HAase)的表达及意义。方法采用免疫组化法,检测21例口腔鳞癌和其切缘无瘤组织中HAase的表达。结果 HAase主要存在于细胞的胞浆中,在肿瘤细胞中表达较切缘无瘤组织细胞中强。高分化鳞癌中HAase阳性表达率比中低分化鳞癌低(P<0.05);伴淋巴结转移的原发病灶中HAase阳性表达率显著高于无淋巴结转移原发灶中的HAase阳性表达率(P<0.05);临床分期为Ⅰ、Ⅱ期的口腔鳞癌组织中HAase阳性表达率与Ⅲ、Ⅳ期的口腔鳞癌组织中HAase阳性表达率无统计学差异(P>0.05)。结论 HAase在口腔鳞癌组织中高表达,并且与分化及颈淋巴结转移有关。

Objective To evaluate the expression of HAase in Oral Squamous Cell Caricinoma(OSCC).MethodsThe distribution and expression of HAase in21patients with OSCC and their resecetions with tumor?free margins were examined by immunohistochemistry method.Results HAase were mainly immunostained in tumor tissue.The expression of HAase in oral cancer with nodal metastasis and low pathological grades were higher than that with no nodal metastasis and high pathological grades(P<0.05),whereas no difference between the TNM stages(P>0.05).Conclusion The HAase levels were high in oral squamous cell carcinoma tissues,and rising in patients with lymph node metastasis and poorly differentiated.