肾性贫血患者血液红细胞及网织红细胞参数临床检验探析

A Clinical Analysis of the Parameters of Erythocytes and Reticulocyte in Patients with Renal Anemia

目的探究肾性贫血患者血液红细胞和网织红细胞参数的变化。方法选择本院2015年12月~2016年12月收治贫血合并慢性肾功能不全患者43例,作为观察组;另选取同期收治的急性失血引发的非肾病贫血患者43例,作为对照组。对比两组血液红细胞和网织红细胞各参数情况。结果①网织红细胞参数水平:观察组LFR显著高于对照组,而RET、RET#、IFR、MFR以及HFR均低于对照组,差异有统计学意义(P<0.05);两组Hb水平的差异无统计学意义(P>0.05)。②血液红细胞参数水平:两组患者的HCT、MCHC、RDW-SD及RDW-CV的差异无统计学意义(P>0.05);观察组MCV、MCH水平均高于对照组,RBC水平低于对照组,差异有统计学意义(P<0.05)。结论肾性贫血患者体内网织红细胞参数中RET、RET#、IFR、MFR及HFR显著降低,LFR水平显著升高,而血液红细胞参数中MCV、MCH水平较高,RBC较低,网织红细胞和血液红细胞参数可作为判断肾性贫血疾病的重要标准。

Objective To study the changes of erythrocyte and reticulocyte parameters in patients with renal anemia.Methods Fourty three patients with anemia associated with renal disfounction(ARD)were collected for for investigation in the hospital from December2015to December2016.The equal number of the patients with anemia caused by hemorrhage rather than renal disorders(AHD)were taken as control.The parameters of red blood cells(RBCs)and reticulocytes between the two groups were compared.Results The LFR of reticulocytes in ARD was significantly higher while the RET,RET#,IFR,MFR and HFR were lower than that in AHD(P<0.05).No significant difference of Hb level between the two groups was observed(P>0.05).Similarly,no remarkable differences of HCT,MCHC,RDW-SD and RDW-CV was seen between the two groups(P>0.05).The levels of MCV and MCH in ARD were notably higher than those in AHD,and the RBCs counts in ARD group was lower than that in AHD(P<0.05).Conclusion The parameters of RET,RET#,IFR,MFR and HFR of reticulocytes in patients with renal anemia are significantly decreased,while the levels of MCF and MCH in blood erythrocytes were increased.Parameters of both red blood blood cells and reticulocytes may be used as an important criterion for the diagnosis of renal anemia.