GC/MS测定一次性使用TPE输液器中苯乙烯单体在紫杉醇注射液中的溶出量

The Release Detection of Styrene Monomer in the Single Disposable TPE Infusion Apparatus on the Condition of Taxol Glucose Injection by GC/MS

本文建立气相色谱/质谱联用法检测输液器中的苯乙烯单体在紫杉醇葡萄糖注射液(0.6mg/ml)中的溶出情况,结果表明:苯乙烯单体在0.1~10μg/ml范围内线性良好,R^2=9998。检测限为0.0004μg,样品加标回收率为94.1%~118.9%,RSD均低于2.16%。该方法操作简单,灵敏度高、快速准确,适用于紫杉醇葡萄糖注射液(0.6mg/ml)^([4])中苯乙烯单体的检测。

This article is aim to demonstrate the dissolved situation of styrene monomer in the infusionapparatus on the condition of Taxol Glucose injection(0.6mg/ml)[4]by GC/MS.The experimentalresults indicated that styrene monomer was with higher linearity in range0.1~10μg/ml,R2=9998,while the LOD was0.0004μg,sample recovery was94.1%~118.9%and the RSD wasunder2.16%.This method is quite simple,sensitive,efficient and accurate that it is suitable fordetecting the content of styrene monomer in Taxol Glucose injection(0.6mg/ml).