帕金森病运动并发症治疗进展

Progress on treatment of Parkinson's disease and its motor complications

帕金森病(Parkinson’s disease,PD)是一种进行性神经元变性疾病。随着病程进展,左旋多巴的疗效逐渐减退,最终出现多种类型运动并发症,主要包括剂末现象、异动症、步态冻结、肌张力障碍;特别是疾病进展期的患者出现异动症及肌张力障碍等并发症时,临床治疗难度大。病程6~9年的PD患者中,41%~70%的患者存在运动并发症。本文通过广泛查阅国内外文献,综述目前处理PD运动并发症的策略,为临床医师认识以及处理PD运动并发症提供参考。

Parkinson's disease(PD)is a progressive neuron degeneration disease,the patient^response to pharmacotherapy decreases as time goes by,resulting in various motor complications,mainly includes wearing-off-,freezing of gait(FOG),dyskinesia,dys-tonia.The occurrence of motor complications is a key component of PD and presents a clinical challenge to practitioners.Especially the occurrence of dyskinesia and dystonia in patients with advanced disease further complicates clinical management.The prevalence of movement problems,is reported to be as high as41%to70%in PD patients after six to nine years of treatment.This article makes a re-view about the way to deal with motor complications through reading literature in detail,so as to provide reference for clinicians under-standing and dealing with motor complications.