免疫球蛋白和T淋巴细胞亚群与支气管哮喘的关系研究

The relationship between immunoglobulin, T lymphocyte subsets and bronchial asthma

目的探讨免疫球蛋白(immunoglobulin,Ig)和T淋巴细胞亚群与支气管哮喘的相关性。方法将本院2015年12月至2016年12月收治的60例支气管哮喘患者纳入观察组,其中,急性发作期23例,缓解期37例;哮喘发作频率:<10次/年20例,10~20次/年30例,>20次/年10例;哮喘严重程度:轻度间歇10例,轻度持续25例,中度持续17例,重度持续8例。同时将本院同期60例健康成年人纳入对照组。比较不同研究对象CD3^+、CD4^+、CD8^+、CD4^+/CD8^+及IgE水平,并采用Pearson相关分析分析其相关性。结果观察组患者CD3^+、CD4^+、CD4^+/CD8^+及IgE水平均明显高于对照组(P<0.05),CD8^+水平明显低于对照组(P<0.05);急性发作期患者CD3^+、CD4^+、CD4^+/CD8^+及IgE水平均明显高于缓解期患者(P<0.05),CD8^+水平明显低于缓解期患者(P<0.05);随着哮喘发作频率和严重程度的增加,患者CD3^+、CD4^+、CD4^+/CD8^+及IgE水平均逐渐升高(P<0.05),CD8^+水平逐渐降低(P<0.05)。Pearson相关分析结果显示:CD3^+、CD4^+、CD4^+/CD8^+及IgE水平与哮喘发作频率均呈正相关(r分别为0.621、0.521、0.498、0.623,P<0.05),与哮喘严重程度均呈正相关(r分别为0.542、0.465、0.449、0.512,P<0.05);CD8^+水平与哮喘发作频率和严重程度均呈负相关(r分别为-0.536、-0.427,P<0.05)。结论支气管哮喘患者CD3^+、CD4^+、CD4^+/CD8^+、IgE水平明显上升,CD8^+水平明显下降,且上述指标水平变化与哮喘发作频率和哮喘严重程度密切相关,对临床治疗哮喘具有指导意义。

Objective To investigate the correlation between the immunoglobulin(Ig),T lymphocyte subsets and bronchial asthma.Method60patients with bronchial asthma from Decebmer2015to December2016in our hospital were included in observation group,acute attack23cases,remission period37cases;asthma severity:mild intermittent10cases,mild persistent25cases,moderate17cases,severe persistent8cases.At the same time,60healthy adults were selected as control group.The levels of CD3+,CD4+,CD8+,CD4+/CD8+,IgE were compared in different subjects,and the correlation was analyzed by Pearson.Result The levels of CD3+,CD4+,CD4+/CD8+and IgE in observation group were significantly higher than those in control group(P<0.05),and CD8+level was significantly lower than that in control group(P<0.05);the levels of CD3+,CD4+,CD4+/CD8+and IgE were significantly higher in acute exacerbation patients than those in remission patients(P<0.05),and the level of CD8+was significantly lower than that in remission patients(P<0.05);with the increase of frequ ency and severity of asthma,the levels of CD3+,CD4+,CD4+/CD8+and IgE were increased(P<0.05),and the level of CD8+was decreased(P<0.05);Pearson analysis showed:the levels of CD3+,CD4+,CD4+/CD8+and IgE were positively correlated with the frequency of asthma(r=0.621,0.521,0.498,0.623,P<0.05),were also positively correlated with the severity of asthma(r=0.542,0.465,0.449,0.512,P<0.05).The level of CD8+was negatively correlated with the frequency and severity of asthma(r=-0.536,-0.427,P<0.05).Conclusion The levels of CD3+,CD4+,CD4+/CD8+,IgE in bronchial asthma patients significantly increase,CD8+level significantly decrease,and the changes of the above indicators are closely related to the severity of asthma,and has guiding significance for clinical treatment of asthma.