肠道微生态失衡与非酒精性脂肪性肝病

Gut microecological imbalance and nonalcoholic fatty liver disease

近年来关于肠道细菌与非酒精性脂肪性肝病关系的研究逐年增多,现已共识肠道微生态失衡导致的肠道菌群过度生长、肠黏膜通透性增加、肠源性内毒素血症、炎症因子产生等在非酒精性脂肪性肝病的发生发展中起到至关重要的作用。研究证明纠正肠道菌群失调可改善胰岛素抵抗、减轻体重和改善糖尿病症状,并使非酒精性脂肪性肝病的炎症得到好转,为非酒精性脂肪性肝病提供了一个新的治疗模式,为非酒精性脂肪性肝病预防也提出了新的认识。

The study on the relationship between intestinal bacteria and nonalcoholic fatty liver disease increases each year.The intestinal microflora imbalance resulted in the intestinal flora overgrowth,the increasing permeability of intestinal mucosa,intestinal endotoxemia,the production of infl ammatory factors plays a vital role in the development of nonalcoholic fatty liver disease.The study shows that the correction of intestinal flora imbalance could improve insulin resistance,lose weight,cure diabetes and ameliorate nonalcoholic fatty liver disease at the same time.The conception on the correction of intestinal flora imbalance could provide a new therapeutic measure and the preventive method for nonalcoholic fatty liver disease.