壳聚糖基水凝胶搭载抗菌剂在伤口愈合中的应用

Application of chitosan-based hydrogels carrying antimicrobial agents in wound healing

背景:随着化学合成技术的发展,壳聚糖基水凝胶在伤口敷料方面的应用已经成为当今研究的热点。目的:介绍壳聚糖基水凝胶,讨论并总结其搭载抗菌剂在伤口愈合方面的应用。方法:作者以"chitosan hydrogel,wound healing,dressing,antimicrobial agents"为关键词,检索2007至2016年期间Pubmed,Web of Science,Springerlink,Medline数据库中相关文献。初检文章168篇,筛选后对76篇文章进行分析。结果与结论:壳聚糖基水凝胶对于由感染引起的慢性难愈合伤口可以发挥其优势,其本身具有抗炎、抗菌性能,可以吸收渗出物,并且在伤口与外界环境之间形成一层薄膜阻挡微生物的入侵,若搭载抗菌剂则可进一步抑制伤口内微生物的生长,从而加速伤口愈合。壳聚糖基水凝胶搭载的抗菌剂主要包括有机抗菌剂和无机抗菌剂两大类,尤其是以纳米银为代表的无机抗菌剂,在微生物耐药性方面表现出独特的优势。

BACKGROUND:With the development of chemical synthesis technology,the application of chitosan-based hydrogels as wound dressing has become a hotspot in current research.OBJECTIVE:To generally introduce the chitosan-based hydrogels and to review and summarize the application of chitosan-based hydrogels carrying antimicrobial agents in wound healing.METHODS:A computer retrieval of PubMed,Web of Science,Springerlink and Medline databases was performed with“chitosan hydrogel,wound healing,dressing,antimicrobial agents”as key words for relevant articles published from2007to2016.Initially,168articles were retrieved,and finally76articles were included in result analysis.RESULTS AND CONCLUSION:Because of their inherent anti-inflammatory and antibacterial properties,chitosan-based hydrogels possess the ability of absorbing exudates and forming thin film between the wound and the external environment,to exert their advantages for chronic,non-healing wounds caused by infection.Furthermore,chitosan-based hydrogels carrying antibacterial agents can inhibit the growth of microorganisms in the wound,accelerating the progress of wound healing.Moreover,the antimicrobial agents,including organic antibacterial agents and inorganic antibacterial agents(especially nano-silver),show unique advantages in wound healing and microbial resistance in combination with chitosan-based hydrogels.