A型肉毒毒素联合强脉冲光在面部小面积瘢痕切除患者中的应用价值研究

The application value of injection of botulinum toxin type A combined with irradiation with intense pulsed light in patients undergoing resection of small facial scar

目的探究A型肉毒毒素(BTX-A)联合强脉冲光(IPL)在面部小面积瘢痕切除患者中的应用价值。方法选取164例行面部小面积瘢痕切除术的患者为研究对象,采用随机数字表法分为BTX-A注射联合IPL照射组(试验组,n=82)和IPL照射组(对照组,n=82)。比较治疗后6个月时两组疗效和不良反应发生情况差异,并记录两组治疗前和治疗后6个月瘢痕情况[患者和观测者瘢痕评价量表(POSAS-OSAS、PSAS)]差异。结果试验组治疗后6个月时显效率与有效率均高于对照组(P<0.05)。两组治疗后6个月时,OSAS评分和PSAS评分均较治疗前降低(P<0.05),且试验组低于对照组(P<0.05)。两组治疗6个月内不良反应发生率比较差异无统计学意义(P>0.05)。结论 BTX-A注射联合IPL照射应用于面部小面积瘢痕切除患者切口愈合治疗中,可有效改善患者瘢痕状态且治疗安全性高,对患者切口愈合疗效较好。

Objective To investigate the application value of injection of botulinum toxin type A(BTX-A)combined with irradiation with intense pulsed light(IPL)in patients undergoing resection of small facial scar.Methods164patients undergoing resection of small facial scar were selected as study subjects,and they were randomly divided into the experimental group(treated with injection of BTX-A combined with irradiation with IPL,n=82)and the control group(treated with irradiation with IPL,n=82).The curative effect and adverse reactions were compared between the groups at6months after treatment.Differences in scar status[evaluated with the the Patient and Observer Scar Assessment Scale(POSAS-OSAS,PSAS)]before treatment and at6months after treatment were observed.Results The markedly effective rate and the effective rate of the experimental group at6months after treatment were higher than those of the control group(P<0.05).Scores of OSAS and PSAS in the two groups at6months after treatment were lower than those before treatment(P<0.05),and the scores in experimental group were lower than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups in6months treatment(P>0.05).Conclusion Injection of BTX-A combined with radiation with IPL can effectively improve the scar status in patients undergoing resection of small facial scar,with high safety.The incision healing effect and curative effect are relatively better.