中老年白癜风患者外周血T细胞亚群的检测与结果研究

Detection and study of peripheral blood T cell subsets in middle-aged and elderly patients with vitiligo

目的研究中老年白癜风患者外周血T细胞亚群的检测与结果。方法研究中选择本院2016年4月到2017年7月的120例白癜风患者,同时选择同期入院的64例体检健康患者,对两组患者的外周血T细胞亚群的检测及结果进行对比分析。结果寻常型进展期患者的CD_3、CD_4均低于对照组,数据统计存在差异(P<0.05),具有统计学意义。而寻常型进展期患者的CD_8会逐渐升高,明显高于对照组,数据统计存在差异(P<0.05),具有统计学意义。稳定期泛发性CD_4/CD_8比值与对照组相比逐渐下降,数据统计存在差异(P<0.05),具有统计学意义。同时,对不同病期患者的CD_3与CD_4检测结果进行了分析,病期在一年以上的寻常型白癜风患者与病期在一年以上的患者相比,CD_3与CD_4明显降低,数据对比存在差异(P<0.05),具有统计学意义。结论不同型期白癜风患者在诊断中存在着不同程度的细胞免疫功能异常现象。

Objective To study the detection and outcome of peripheral blood T cell subsets in middle-aged and elderly patients with vitiligo.Methods A total of120patients with vitiligo were enrolled in our hospital from April2016to July2017,and64healthy subjects were selected.The peripheral blood T cell subsets of the two groups were compared and the results were compared.analysis.Results C D3and CD4were lower in the patients with normal type than in the control group,and there was significant difference between the two groups(P<0.05),which was statistically significant.(P<0.05),and there was significant difference between the two groups(P<0.05),and the difference was statistically significant(P<0.05).The ratio of CD8in the stable phase decreased gradually compared with the control group,and the difference was statistically significant(P<0.05),which was statistically significant.At the same time,the CD3and CD4test results were analyzed for patients with different stages of disease.CD3and CD4were significantly lower in patients with normal vitiligo than those with more than one year.(P<0.05),which was statistically significant.Conclusion There are different degrees of abnormal cellular immune function in patients with different types of vitiligo.