脂肪因子Vaspin、Apelin及瘦素与多囊卵巢综合征的相关性

The Relationship Between Polycystic Ovary Syndrome and Vaspin,Apelin and Leptin

目的探讨脂肪因子Vaspin、Apelin及瘦素(Leptin)与多囊卵巢综合征(polycystic ovary syndrome,PCOS)相关性.方法测定40例PCOS患者及30例对照组的血清Vaspin、Apelin及瘦素水平,并将PCOS组按WHO肥胖标准分为体重正常组、超重组及肥胖组,分析血清Vaspin、Apelin及瘦素水平在PCOS与对照组中的差异和在不同体重指数(Body mass index,BMI)PCOS患者中的差异,探讨脂肪因子Vaspin、Apelin及瘦素在PCOS发病机制中的作用.结果 PCOS患者脂肪因子Vaspin、Apelin、瘦素、胰岛素抵抗指数(Homeostasis model assessment for Insulin resistence index,HOMA-IR)、空腹胰岛素(Lnsulin,INS)及血糖、血脂高于对照组,随着BMI的增加而升高,且三种脂肪因子与PCOS患者HOMA-IR正相关,差异有统计学意义(P<0.05).结论脂肪因子vaspin、apelin及瘦素可能参与了PCOS的发生.

Objective To investigate the relationship between vaspin,Apelin,leptin and polycystic ovarysyndrome.Methods We determined the serum vaspin,Apelin and leptin levels of40cases of PCOS patients and30cases of control group,and divided the PCOS group into three subgroups(normal weight,overweight andobesity)according to WHO criteria for obesity.Then we compared the serum vaspin,Apelin and leptin levels inPCOS and control group,and the differences in body weight index(body mass index,BMI)in women withpolycystic ovary syndrome,and analyzed roles of adipokine vaspin,Apelin and leptin in the pathogenesis of PCOS.Results In PCOS patients adipokine vaspin,Apelin,leptin,insulin resistance index(Homeostasis modelassessment for insulin index in resistence,HOMA-IR),fasting insulin(INS)and blood glucose,blood lipidwere higher than those of the control group and increased with the increase of body mass index(BMI),and threekinds of adipokines and PCOS patients with HOMA-IR were positively correlated,there were statistically significantdifferences(P<0.05).Conclusion The results of vaspin,Apelin and leptin may be involved in the occurrenceof PCOS.