DOSE指数评分系统在慢性阻塞性肺疾病中的应用价值

Application value of DOSE Index Scoring System in Chronic Obstructive Pulmonary Disease

目的探讨DOSE指数评分在慢性阻塞性肺疾病评价中的应用价值.方法对122例稳定期COPD患者连续随访12个月,统计并记录患者的健康及生活情况.同时对COPD患者FEV1、DOSE进行评分,并记录COPD危险事件,包括呼吸衰竭和死亡、就诊次数、住院次数、总住院日,门诊费用,住院费用,m MRC,年急性加重次数评分等.结果 122例COPD稳定期患者DOSE指数评分与FEV1%pred呈负相关(r=-0.73,P<0.05);与m MRC(r=085,P<0.01),急性加重次数(r=0.71,P<0.01),呼吸衰竭(r=0.65,P<0.01),心衰(r=0.50,P<0.01),门诊次数(r=0.12,P<0.01),住院次数(r=0.70,P<0.01),总住院日(r=0.66,P<0.01),门诊费用(r=0.13,P>0.05),住院费用(r=0.65,P<0.01)均呈正相关.ROC曲线分析记录COPD患者的DOSE指数的截断点和曲线面积.结论 DOSE指数是一简单易行的COPD评估工具,与患者的预后及健康状况密切相关.

Objective To explore the application value of DOSE index score in the peitients with chronicobstructive pulmonary disease.Methods122cases of plateau COPD patients were followed up for12months,and we recorded and analyzed the patient's health and life.We also recorde FEV1and DOSE scores of the patientswith COPD,and record the COPD risk events,including the number of respiratory failure and death,and the timesof hospitalization,total such confinement,outpatient expenses,hospitalization expenses,mMRC,and scored inthe number of exacerbations,etc.Results The DOSE index score was negatively correlated with FEV1%pred(r=0.73,P<0.05)for122COPD patients,and were positively correlated with mMRC(r=085,P<0.01),the annual number of exacerbations(r=0.71,P<0.01),respiratory failure(r=0.65,P<0.01),heart failure(r=0.50,P<0.01),number of outpatient service(r=0.12,P<0.01),hospitalization time(r=0.70,P<0.01),the total such confinement(r=0.66,P<0.01),outpatient expenses(r=0.13,P>0.13),hospitalization expenses(r=0.65,P<0.01).ROC curve was used to analyzed the cut-off point andcurve area of COPD DOSE index.Conclusion The DOSE index is a simple COPD assessment tools,and isclosely related to the prognosis of patients and health.