醋柳黄酮治疗非典型抗精神病药物所致血脂异常的疗效观察

The therapeutic effect of acetylflavone in the treatment of atypical antipsychotics was observed

目的探讨醋柳黄酮治疗非典型抗精神病药物引起的精神分裂症患者血脂异常的疗效及安全性。方法选取2016年9月~2017年2月在赣州市第三人民医院精神科门诊诊治的精神分裂症患者100例,随机分为研究组和对照组,每组各50例。研究组在予以辛伐他汀胶囊调脂治疗的基础上联合醋柳黄酮口服,对照组仅予以辛伐他汀胶囊口服调脂治疗。对两组病例分别于基线、治疗第2周末及治疗第6周末测定患者血LDL-C水平,同时对治疗期间出现的不良反应进行监测。结果治疗第6周末,研究组完成41例,脱落9例,对照组完成42例,脱落8例。两组患者性别、年龄及抗精神病药物使用情况等方面比较差异无统计学意义。基线时及治疗第2周末LDL-C值组间比较均差异无统计学意义。治疗第6周末时,研究组LDL-C值显著低于对照组,差异有统计学意义(P<0.05)。研究组有效率90.2%;对照组有效率71.4%。研究组治疗有效率高于对照组,差异有统计学意义(P<0.05)。结论醋柳黄酮能更加有效的对非典型抗精神病药物引起的血脂异常进行调节,减少精神分裂症患者药物治疗引起的心血管疾病风险,而且安全可靠,能更加利于精神分裂症患者的全面康复,值得临床推广。

Objective To investigate the efficacy and safety of the treatment of blood lipid in patients with atypical antipsychotics in patientswith atypical antipsychotics.Methods100patients with schizophrenia were selected from the psychiatric outpatient department of the third people'shospital of ganzhou from September2016to February2017,and randomly divided into the study group and the control group,with50cases each.The team combined the treatment of simvastatin capsules with acetone flavone orally.The control group was treated with simvastatin capsule.Theblood ldl-c levels were measured at baseline and in treatment of the second weekend and the6th weekend of treatment.During the treatment period,adverse reactions were monitored.Results In the6th weekend,the team completed41cases,fell off9cases,and the control group completed42cases and dropped8cases.There was no statistically significant difference between the two groups in terms of sex,age and the use of antipsychoticdrugs.There was no statistically significant difference between LDL-C values in the baseline and the second weekend.At the end of the sixth weekend,the group's LDL-C value was significantly lower than the control group,and the difference was statistically significant(P<0.05).The team waseffective90.2%;the control group was71.4%effective.The treatment rate of the study group was higher than the control group(P<0.05).Conclu?sion Flavones of flavonoids can be more effective for dyslipidemia caused by atypical antipsychotics adjustment,reduce the patients with schizophreniadrug treatment caused by cardiovascular disease risk,and safe and reliable,and can be more conducive to the comprehensive rehabilitation ofschizophrenia patients,worth clinical promotion.