放疗同步替吉奥联合恩度对老年食管癌患者的疗效观察

Clinical application of radiotheropy combined with endostar and S1 in the elderly esophageal cancer patients

目的探讨恩度联合放疗同步替吉奥治疗老年食管癌患者的近期疗效。方法选择本院2013年3月~2015年3月间确诊的47例老年食管癌患者(年龄≥65岁),随机分为两组。对照组24例患者行放疗同步替吉奥治疗,观察组23例在对照组治疗方案的基础上加用恩度,比较两组患者的临床疗效、不良反应和生存质量。结果观察组有效率和生存质量较对照组高(82.6%vs 70.8%,78.3%vs 62.5%),但组间差异均无统计学意义。观察组和对照组间不良反应差异无统计学意义。结论恩度联合放疗同步替吉奥治疗老年食管癌患者可能提高疗效并改善患者的生存质量,值得进一步研究。

Objective To observe the clinical effect of radiotheropy combined with endostar and S-1in the elderly esophageal cancer patients.Methods Forty-seven patiens with esophageal cancer(age≥65years old)from March2013to March2015in The Second Affiliated Hospital ofBaotou Medical College were randomly into treatment group and control group.The control group was treated with radiotheropy and S-1,while thetreatment group was given radiotheropy combined with endostar and S-1.Clinical effects were compared between the treatment group and the controlgroup after treatment.Results The efficiency and quality of observation group was higher than that of control group(62.5%vs.70.8%,78.3%vs.82.6%),but there was no significant difference between the groups.There was no significant difference between the two groups in the observationgroup and the control group.Conclusion Endostar combined with synchronous radiotherapy S-1in the treatment of elderly patients with esophagealcancer may improve the curative effect and improve the patient's quality of life,worthy of further study.